Product nameRecombinant human Eph receptor A1/EphA1 protein
See all Eph receptor A1/EphA1 proteins and peptides
Protein lengthProtein fragment
Amino Acid Sequence
Molecular weight72 kDa including tags
Amino acids569 to 976
Our Abpromise guarantee covers the use of ab101778 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Biological activityThe Specific activity of ab101778 was determined to be 28 nmol/min/mg.
Purity> 90 % Densitometry.
Purity was determined to be >90% by densitometry.
ab204877 (Poly (4:1 Glu, Tyr) peptide) can be utilized as a substrate for assessing kinase activity
Previously labelled as Eph receptor A1.
Concentration information loading...
Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
Constituents: 0.307% Glutathione, 0.00174% PMSF, 0.00385% DTT, 0.79% Tris HCl, 0.00292% EDTA, 25% Glycerol, 0.87% Sodium chloride
This product is an active protein and may elicit a biological response in vivo, handle with caution.
- EPH receptor A1
- EPH tyrosine kinase
FunctionReceptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds with a low affinity EFNA3 and EFNA4 and with a high affinity to EFNA1 which most probably constitutes its cognate/functional ligand. Upon activation by EFNA1 induces cell attachment to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and downstream RHOA and RAC. Plays also a role in angiogenesis and regulates cell proliferation. May play a role in apoptosis.
Tissue specificityOverexpressed in several carcinomas.
Sequence similaritiesBelongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
Contains 1 Eph LBD (Eph ligand-binding) domain.
Contains 2 fibronectin type-III domains.
Contains 1 protein kinase domain.
Contains 1 SAM (sterile alpha motif) domain.
modificationsPhosphorylated. Autophosphorylation is stimulated by its ligand EFNA1.
Cellular localizationCell membrane.
- Information by UniProt
ab101778 has not yet been referenced specifically in any publications.