Recombinant Human Eph receptor A1/EphA1 protein (His tag) (ab215603)

Description

  • Product name

    Recombinant Human Eph receptor A1/EphA1 protein (His tag)
    See all Eph receptor A1/EphA1 proteins and peptides
  • Purity

    > 95 % SDS-PAGE.

  • Endotoxin level

    < 1.000 Eu/µg
  • Expression system

    Mammalian
  • Accession

  • Protein length

    Protein fragment
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Human
    • Sequence

      KEVTLMDTSKAQGELGWLLDPPKDGWSEQQQILNGTPLYMYQDCPMQGRR DTDHWLRSNWIYRGEEASRVHVELQFTVRDCKSFPGGAGPLGCKETFNLL YMESDQDVGIQLRRPLFQKVTTVAADQSFTIRDLASGSVKLNVERCSLGR LTRRGLYLAFHNPGACVALVSVRVFYQRCPETLNGLAQFPDTLPGPAGLV EVAGTCLPHARASPRPSGAPRMHCSPDGEWLVPVGRCHCEPGYEEGGSGE ACVACPSGSYRMDMDTPHCLTCPQQSTAESEGATICTCESGHYRAPGEGP QVACTGPPSAPRNLSFSASGTQLSLRWEPPADTGGRQDVRYSVRCSQCQG TAQDGGPCQPCGVGVHFSPGARGLTTPAVHVNGLEPYANYTFNVEAQNGV SGLGSSGHASTSVSISMGHAESLSGLSLRLVKKEPRQLELTWAGSRPRSP GANLTYELHVLNQDEERYQMVLEPRVLLTELQPDTTYIVRVRMLTPLGPG PFSPDHEFRTSPPVSRGLTGGEHHHHHH
    • Predicted molecular weight

      57 kDa including tags
    • Amino acids

      26 to 547
    • Tags

      His tag C-Terminus

Specifications

Our Abpromise guarantee covers the use of ab215603 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Form

    Lyophilised
  • Additional notes

    Previously labelled as Eph receptor A1.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20°C. Avoid freeze / thaw cycle.

    pH: 7.40
    Constituent: 100% PBS

    Lyophilized from a 0.2 µm filtered solution.

  • Reconstitution
    Dissolve the lyophilized protein in ddH2O. It is not recommended to reconstitute to a concentration less than 100 µg/ml.

General Info

  • Alternative names

    • EPH
    • EPH receptor A1
    • EPH tyrosine kinase
    • EPH tyrosine kinase 1
    • Epha1
    • EPHA1_HUMAN
    • Ephrin receptor Eph A1
    • Ephrin type A receptor 1
    • Ephrin type-A receptor 1
    • EPHT
    • EPHT 1
    • EPHT1
    • Erythropoietin producing hepatoma amplified sequence
    • Erythropoietin-producing hepatoma receptor
    • Esk
    • hEpha1
    • MGC163163
    • Oncogene EPH
    • Soluble EPHA1 variant 1
    • Soluble EPHA1 variant 2
    • Tyrosine protein kinase receptor EPH
    • Tyrosine-protein kinase receptor EPH
    see all
  • Function

    Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds with a low affinity EFNA3 and EFNA4 and with a high affinity to EFNA1 which most probably constitutes its cognate/functional ligand. Upon activation by EFNA1 induces cell attachment to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and downstream RHOA and RAC. Plays also a role in angiogenesis and regulates cell proliferation. May play a role in apoptosis.
  • Tissue specificity

    Overexpressed in several carcinomas.
  • Sequence similarities

    Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
    Contains 1 Eph LBD (Eph ligand-binding) domain.
    Contains 2 fibronectin type-III domains.
    Contains 1 protein kinase domain.
    Contains 1 SAM (sterile alpha motif) domain.
  • Post-translational
    modifications

    Phosphorylated. Autophosphorylation is stimulated by its ligand EFNA1.
    Ubiquitinated.
  • Cellular localization

    Cell membrane.
  • Information by UniProt

References

ab215603 has not yet been referenced specifically in any publications.

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