Recombinant Human Ephrin B2 protein (ab92862)
Key features and details
- Expression system: HEK 293 cells
- Purity: > 99% SDS-PAGE
- Tags: His tag C-Terminus, Fc tag C-Terminus
- Suitable for: WB, ELISA, SDS-PAGE
Description
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Product name
Recombinant Human Ephrin B2 protein
See all Ephrin B2 proteins and peptides -
Purity
> 99 % SDS-PAGE.
Purified by affinity chromatography. -
Expression system
HEK 293 cells -
Protein length
Protein fragment -
Animal free
No -
Nature
Recombinant -
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Species
Human -
Amino acids
1 to 227 -
Tags
His tag C-Terminus , Fc tag C-Terminus
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Associated products
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Related Products
Specifications
Our Abpromise guarantee covers the use of ab92862 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Applications
Western blot
ELISA
SDS-PAGE
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Form
Lyophilized -
Additional notes
After reconstitution, store in working aliquots at -80ºC. -
Concentration information loading...
Preparation and Storage
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Stability and Storage
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at +4°C. Please see notes section.
pH: 7.40
Constituent: PBS -
ReconstitutionPlease add 20ul of PBS to make 0.5mg/ml
General Info
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Alternative names
- EFN B2
- EFNB 2
- Efnb2
see all -
Function
Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds to receptor tyrosine kinase including EPHA4, EPHA3 and EPHB4. Together with EPHB4 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. May play a role in constraining the orientation of longitudinally projecting axons.
(Microbial infection) Acts as a receptor for Hendra virus and Nipah virus. -
Tissue specificity
Lung and kidney. -
Sequence similarities
Belongs to the ephrin family.
Contains 1 ephrin RBD (ephrin receptor-binding) domain. -
Post-translational
modificationsInducible phosphorylation of tyrosine residues in the cytoplasmic domain. -
Cellular localization
Membrane. - Information by UniProt
Images
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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Datasheet download
References (0)
ab92862 has not yet been referenced specifically in any publications.