Recombinant Human Epsin 2 protein (ab161471)

Our Abpromise guarantee covers the use of ab161471 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Alternative names
- EHB21
- EPN 2
- Epn2
- EPN2_HUMAN
- EPS 15 interacting protein 2
- EPS-15-interacting protein 2
- Eps15 binding protein
- Epsin 2
- Epsin-2
- Epsin2
- KIAA1065
- OTTHUMP00000065808
- OTTHUMP00000065809
- OTTHUMP00000065810
- OTTHUMP00000065811
- OTTHUMP00000065889
see all
Function

Plays a role in the formation of clathrin-coated invaginations and endocytosis.
Tissue specificity

Highest expression is found in brain. Detected at lower levels in lung and liver.
Sequence similarities

Belongs to the epsin family.
Contains 1 ENTH (epsin N-terminal homology) domain.
Contains 2 UIM (ubiquitin-interacting motif) repeats.
Domain

The NPF repeat domain is involved in EPS15 binding.
The DPW repeat domain is involved in AP-2 and clathrin binding.
Post-translational
modifications

Ubiquitinated.
Cellular localization

Cytoplasm. Cytoplasmic vesicle > clathrin-coated vesicle. In punctate structures throughout the cell, associated with clathrin-coated vesicles, and particularly concentrated in the region of the Golgi complex.
Target information above from: UniProt accession O95208 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt

SDS-PAGE - Recombinant Human Epsin 2 protein (ab161471)

ab161471 on a 12.5% SDS-PAGE stained with Coomassie Blue.

ab161471 has not yet been referenced specifically in any publications.

Publishing research using ab161471? Please let us know so that we can cite the reference in this datasheet.

Customer reviews and Q&As

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"