Recombinant Human EPX protein (ab152846)

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SDS-PAGE - Recombinant Human EPX protein (ab152846)

    Key features and details

    • Expression system: Wheat germ
    • Suitable for: ELISA, SDS-PAGE, WB

    Description

    • Product name

      Recombinant Human EPX protein

    • Expression system

      Wheat germ

    • Accession

      P11678

    • Protein length

      Full length protein

    • Animal free

      No

    • Nature

      Recombinant

      • Species

        Human

      • Sequence

        MHLLPALAGVLATLVLAQPCEGTDPASPGAVETSVLRDCIAEAKLLVDAA YNWTQKSIKQRLRSGSASPMDLLSYFKQPVAATRTVVRAADYMHVALGLL EEKLQPQRSGPFNVTDVLTEPQLRLLSQASGCALRDQAERCSDKYRTITG RCNNKRRPLLGASNQALARWLPAEYEDGLSLPFGWTPSRRRNGFLLPLVR AVSNQIVRFPNERLTSDRGRALMFMQWGQFIDHDLDFSPESPARVAFTAG VDCERTCAQLPPCFPIKIPPNDPRIKNQRDCIPFFRSAPSCPQNKNRVRN QINALTSFVDASMVYGSEVSLSLRLRNRTNYLGLLAINQRFQDNGRALLP FDNLHDDPCLLTNRSARIPCFLAGDTRSTETPKLAAMHTLFMREHNRLAT ELRRLNPRWNGDKLYNEARKIMGAMVQIITYRDFLPLVLGKARARRTLGH YRGYCSNVDPRVANVFTLAFRFGHTMLQPFMFRLDSQYRASAPNSHVPLS SAFFASWRIVYEGGIDPILRGLMATPAKLNRQDAMLVDELRDRLFRQVRR IGLDLAALNMQRSRDHGLPGYNAWRRFCGLSQPRNLAQLSRVLKNQDLAR KFLNLYGTPDNIDIWIGAIAEPLLPGARVGPLLACLFENQFRRARDGDRF WWQKRGVFTKRQRKALSRISLSRIICDNTGITTVSRDIFRANIYPRGFVN CSRIPRLNLSAWRGT

      • Predicted molecular weight

        106 kDa including tags

      • Amino acids

        1 to 715

    Associated products

    Specifications

    Our Abpromise guarantee covers the use of ab152846 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • Applications

      ELISA

      SDS-PAGE

      Western blot

    • Form

      Liquid

    • Additional notes

       

       

    • Concentration information loading...

    Preparation and Storage

    • Stability and Storage

      Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

      pH: 8.00
      Constituents: 0.31% Glutathione, 0.79% Tris HCl

    General Info

    • Alternative names

      • Eosinophil peroxidase
      • Eosinophil peroxidase [Precursor]
      • Eosinophil peroxidase heavy chain
      • EPER
      • EPO
      • EPP
      • EPX
      • EPX PEN
      • PERE
      • PERE_HUMAN
      see all

    • Function

      Mediates tyrosine nitration of secondary granule proteins in mature resting eosinophils. Shows significant inhibitory activity towards Mycobacterium tuberculosis H37Rv by inducing bacterial fragmentation and lysis.

    • Involvement in disease

      Defects in EPX are the cause of eosinophil peroxidase deficiency (EPD) [MIM:261500]. EPD is an autosomal recessive defect where anomalous eosinophils are characterized by nuclear hypersegmentation, hypogranulation, and negative peroxidase and phospholipid staining.

    • Sequence similarities

      Belongs to the peroxidase family. XPO subfamily.

    • Cellular localization

      Cytoplasmic granule. Cytoplasmic granules of eosinophils.
    • Information by UniProt

    Images

    • SDS-PAGE - Recombinant Human EPX protein (ab152846)
      SDS-PAGE - Recombinant Human EPX protein (ab152846)
      12.5% SDS-PAGE analysis of ab152846 stained with Coomassie Blue.

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    References (0)

    Publishing research using ab152846? Please let us know so that we can cite the reference in this datasheet.

    ab152846 has not yet been referenced specifically in any publications.

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