Recombinant Human EPX protein (ab152846)

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Description

  • Product name

    Recombinant Human EPX protein

  • Expression system

    Wheat germ

  • Accession

    P11678

  • Protein length

    Full length protein

  • Animal free

    No

  • Nature

    Recombinant

    • Species

      Human

    • Sequence

      MHLLPALAGVLATLVLAQPCEGTDPASPGAVETSVLRDCIAEAKLLVDAA YNWTQKSIKQRLRSGSASPMDLLSYFKQPVAATRTVVRAADYMHVALGLL EEKLQPQRSGPFNVTDVLTEPQLRLLSQASGCALRDQAERCSDKYRTITG RCNNKRRPLLGASNQALARWLPAEYEDGLSLPFGWTPSRRRNGFLLPLVR AVSNQIVRFPNERLTSDRGRALMFMQWGQFIDHDLDFSPESPARVAFTAG VDCERTCAQLPPCFPIKIPPNDPRIKNQRDCIPFFRSAPSCPQNKNRVRN QINALTSFVDASMVYGSEVSLSLRLRNRTNYLGLLAINQRFQDNGRALLP FDNLHDDPCLLTNRSARIPCFLAGDTRSTETPKLAAMHTLFMREHNRLAT ELRRLNPRWNGDKLYNEARKIMGAMVQIITYRDFLPLVLGKARARRTLGH YRGYCSNVDPRVANVFTLAFRFGHTMLQPFMFRLDSQYRASAPNSHVPLS SAFFASWRIVYEGGIDPILRGLMATPAKLNRQDAMLVDELRDRLFRQVRR IGLDLAALNMQRSRDHGLPGYNAWRRFCGLSQPRNLAQLSRVLKNQDLAR KFLNLYGTPDNIDIWIGAIAEPLLPGARVGPLLACLFENQFRRARDGDRF WWQKRGVFTKRQRKALSRISLSRIICDNTGITTVSRDIFRANIYPRGFVN CSRIPRLNLSAWRGT

    • Predicted molecular weight

      106 kDa including tags

    • Amino acids

      1 to 715

Associated products

Specifications

Our Abpromise guarantee covers the use of ab152846 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    ELISA

    SDS-PAGE

    Western blot

  • Form

    Liquid

  • Additional notes

     

     

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names

    • Eosinophil peroxidase
    • Eosinophil peroxidase [Precursor]
    • Eosinophil peroxidase heavy chain
    • EPER
    • EPO
    • EPP
    • EPX
    • EPX PEN
    • PERE
    • PERE_HUMAN
    see all

  • Function

    Mediates tyrosine nitration of secondary granule proteins in mature resting eosinophils. Shows significant inhibitory activity towards Mycobacterium tuberculosis H37Rv by inducing bacterial fragmentation and lysis.

  • Involvement in disease

    Defects in EPX are the cause of eosinophil peroxidase deficiency (EPD) [MIM:261500]. EPD is an autosomal recessive defect where anomalous eosinophils are characterized by nuclear hypersegmentation, hypogranulation, and negative peroxidase and phospholipid staining.

  • Sequence similarities

    Belongs to the peroxidase family. XPO subfamily.

  • Cellular localization

    Cytoplasmic granule. Cytoplasmic granules of eosinophils.
  • Information by UniProt

Images

  • SDS-PAGE - Recombinant Human EPX protein (ab152846)
    SDS-PAGE - Recombinant Human EPX protein (ab152846)
    12.5% SDS-PAGE analysis of ab152846 stained with Coomassie Blue.

References

ab152846 has not yet been referenced specifically in any publications.

Publishing research using ab152846? Please let us know so that we can cite the reference in this datasheet.

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