Overview

  • Product name
    Recombinant Human EPX protein
  • Protein length
    Full length protein

Description

  • Nature
    Recombinant
  • Source
    Wheat germ
  • Amino Acid Sequence
    • Accession
      P11678
    • Species
      Human
    • Sequence
      MHLLPALAGVLATLVLAQPCEGTDPASPGAVETSVLRDCIAEAKLLVDAA YNWTQKSIKQRLRSGSASPMDLLSYFKQPVAATRTVVRAADYMHVALGLL EEKLQPQRSGPFNVTDVLTEPQLRLLSQASGCALRDQAERCSDKYRTITG RCNNKRRPLLGASNQALARWLPAEYEDGLSLPFGWTPSRRRNGFLLPLVR AVSNQIVRFPNERLTSDRGRALMFMQWGQFIDHDLDFSPESPARVAFTAG VDCERTCAQLPPCFPIKIPPNDPRIKNQRDCIPFFRSAPSCPQNKNRVRN QINALTSFVDASMVYGSEVSLSLRLRNRTNYLGLLAINQRFQDNGRALLP FDNLHDDPCLLTNRSARIPCFLAGDTRSTETPKLAAMHTLFMREHNRLAT ELRRLNPRWNGDKLYNEARKIMGAMVQIITYRDFLPLVLGKARARRTLGH YRGYCSNVDPRVANVFTLAFRFGHTMLQPFMFRLDSQYRASAPNSHVPLS SAFFASWRIVYEGGIDPILRGLMATPAKLNRQDAMLVDELRDRLFRQVRR IGLDLAALNMQRSRDHGLPGYNAWRRFCGLSQPRNLAQLSRVLKNQDLAR KFLNLYGTPDNIDIWIGAIAEPLLPGARVGPLLACLFENQFRRARDGDRF WWQKRGVFTKRQRKALSRISLSRIICDNTGITTVSRDIFRANIYPRGFVN CSRIPRLNLSAWRGT
    • Molecular weight
      106 kDa including tags
    • Amino acids
      1 to 715

Associated products

Specifications

Our Abpromise guarantee covers the use of ab152846 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    ELISA

    SDS-PAGE

    Western blot

  • Form
    Liquid
  • Additional notes
    Protein concentration is above or equal to 0.05 µg/µl.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names
    • Eosinophil peroxidase
    • Eosinophil peroxidase [Precursor]
    • Eosinophil peroxidase heavy chain
    • EPER
    • EPO
    • EPP
    • EPX
    • EPX PEN
    • PERE
    • PERE_HUMAN
    see all
  • Function
    Mediates tyrosine nitration of secondary granule proteins in mature resting eosinophils. Shows significant inhibitory activity towards Mycobacterium tuberculosis H37Rv by inducing bacterial fragmentation and lysis.
  • Involvement in disease
    Defects in EPX are the cause of eosinophil peroxidase deficiency (EPD) [MIM:261500]. EPD is an autosomal recessive defect where anomalous eosinophils are characterized by nuclear hypersegmentation, hypogranulation, and negative peroxidase and phospholipid staining.
  • Sequence similarities
    Belongs to the peroxidase family. XPO subfamily.
  • Cellular localization
    Cytoplasmic granule. Cytoplasmic granules of eosinophils.
  • Information by UniProt

Images

  • SDS-PAGE - Recombinant Human EPX protein (ab152846)
    SDS-PAGE - Recombinant Human EPX protein (ab152846)
    12.5% SDS-PAGE analysis of ab152846 stained with Coomassie Blue.

References

ab152846 has not yet been referenced specifically in any publications.

Publishing research using ab152846? Please let us know so that we can cite the reference in this datasheet.

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