Name: Recombinant Human ERF protein
SKU: ab158383

Our Abpromise guarantee covers the use of ab158383 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Alternative names
- ERF
- ERF_HUMAN
- ETS domain containing transcription factor ERF
- ETS domain-containing transcription factor ERF
- Ets2 repressor factor
- PE 2
- PE-2
- PE2
see all
Function

Potent transcriptional repressor that binds to the H1 element of the Ets2 promoter. May regulate other genes involved in cellular proliferation. Required for extraembryonic ectoderm differentiation, ectoplacental cone cavity closure, and chorioallantoic attachment (By similarity). May be important for regulating trophoblast stem cell differentiation.
Tissue specificity

Highest levels in testis, ovary, pancreas, and heart.
Sequence similarities

Belongs to the ETS family.
Contains 1 ETS DNA-binding domain.
Post-translational
modifications

Phosphorylated by multiple kinases including MAPK1/ERK2 at THR-526. Phosphorylation regulates the activity of ERF.
Cellular localization

Nucleus.
Target information above from: UniProt accession P50548 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt

SDS-PAGE - Recombinant Human ERF protein (ab158383)

ab158383 on a 12.5% SDS-PAGE stained with Coomassie Blue.

ab158383 has not yet been referenced specifically in any publications.

Publishing research using ab158383? Please let us know so that we can cite the reference in this datasheet.

Customer reviews and Q&As

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

Recombinant Human ERF protein (ab158383)