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    recombinant-human-erk2-protein-ab95379.pdf

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Neuroscience Neurotransmission Intracellular Signaling Kinases
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Recombinant Human ERK2 protein (ab95379)

  • Datasheet
  • SDS
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SDS-PAGE - Recombinant Human ERK2 protein (ab95379)

    Key features and details

    • Expression system: Escherichia coli
    • Purity: > 95% SDS-PAGE
    • Suitable for: SDS-PAGE

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    Description

    • Product name

      Recombinant Human ERK2 protein
      See all ERK2 proteins and peptides
    • Purity

      > 95 % SDS-PAGE.
      purified by using conventional chromatography techniques
    • Expression system

      Escherichia coli
    • Protein length

      Full length protein
    • Animal free

      No
    • Nature

      Recombinant
      • Species

        Human
      • Sequence

        MGSSHHHHHH SSGLVPRGSH MAAAAAAGAG PEMVRGQVFD VGPRYTNLSY IGEGAYGMVC SAYDNVNKVR VAIKKISPFE HQTYCQRTLR EIKILLRFRH ENIIGINDII RAPTIEQMKD VYIVQDLMET DLYKLLKTQH LSNDHICYFL YQILRGLKYI HSANVLHRDL KPSNLLLNTT CDLKICDFGL ARVADPDHDH TGFLTEYVAT RWYRAPEIML NSKGYTKSID IWSVGCILAE MLSNRPIFPG KHYLDQLNHI LGILGSPSQE DLNCIINLKA RNYLLSLPHK NKVPWNRLFP NADSKALDLL DKMLTFNPHK RIEVEQALAH PYLEQYYDPS DEPIAEAPFK FDMELDDLPK EKLKELIFEE TARFQPGYRS

    Associated products

    • Related Products

      • Anti-6X His tag® antibody [HIS.H8] (ab18184)
      • Anti-6X His tag® antibody [4D11] (ab5000)

    Specifications

    Our Abpromise guarantee covers the use of ab95379 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • Applications

      SDS-PAGE

    • Form

      Liquid
    • Concentration information loading...

    Preparation and Storage

    • Stability and Storage

      Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

      pH: 8.00
      Constituents: 0.0154% DTT, 0.316% Tris HCl, 10% Glycerol (glycerin, glycerine)

    General Info

    • Alternative names

      • ERK 2
      • ERK-2
      • ERT1
      • Extracellular Signal Regulated Kinase 2
      • Extracellular signal-regulated kinase 2
      • MAP kinase 1
      • MAP kinase 2
      • MAP kinase isoform p42
      • MAPK 1
      • MAPK 2
      • Mapk1
      • MAPK2
      • Mitogen-activated protein kinase 1
      • Mitogen-activated protein kinase 2
      • MK01_HUMAN
      • P38
      • P40
      • P41
      • p42-MAPK
      • P42MAPK
      • PRKM1
      • PRKM2
      • protein kinase, mitogen-activated, 1
      • protein kinase, mitogen-activated, 2
      • protein tyrosine kinase ERK2
      see all
    • Function

      Involved in both the initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors such as ELK1. Phosphorylates EIF4EBP1; required for initiation of translation. Phosphorylates microtubule-associated protein 2 (MAP2). Phosphorylates SPZ1 (By similarity). Phosphorylates heat shock factor protein 4 (HSF4) and ARHGEF2.
      Acts as a transcriptional repressor. Binds to a [GC]AAA[GC] consensus sequence. Repress the expression of interferon gamma-induced genes. Seems to bind to the promoter of CCL5, DMP1, IFIH1, IFITM1, IRF7, IRF9, LAMP3, OAS1, OAS2, OAS3 and STAT1. Transcriptional activity is independent of kinase activity.
    • Sequence similarities

      Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
      Contains 1 protein kinase domain.
    • Domain

      The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
    • Post-translational
      modifications

      Dually phosphorylated on Thr-185 and Tyr-187, which activates the enzyme. Dephosphorylated by PTPRJ at Tyr-187.
    • Cellular localization

      Nucleus.
    • Target information above from: UniProt accession P28482 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt

    Images

    • SDS-PAGE - Recombinant Human ERK2 protein (ab95379)
      SDS-PAGE - Recombinant Human ERK2 protein (ab95379)

      15% SDS-PAGE image (3ug) generated using ab95379

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    Datasheets and documents

    • SDS download

    • Datasheet download

      Download

    References (0)

    Publishing research using ab95379? Please let us know so that we can cite the reference in this datasheet.

    ab95379 has not yet been referenced specifically in any publications.

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