Overview

Description

  • Nature

    Recombinant
  • Source

    Wheat germ
  • Amino Acid Sequence
    • Accession
    • Species

      Human
    • Sequence

      MAATCEISNIFSNYFSAMYSSEDSTLASVPPAATFGADDLVLTLSNPQMS LEGTEKASWLGEQPQFWSKTQVLDWISYQVEKNKYDASAIDFSRCDMDGA TLCNCALEELRLVFGPLGDQLHAQLRDLTSSSSDELSWIIELLEKDGMAF QEALDPGPFDQGSPFAQELLDDGQQASPYHPGSCGAGAPSPGSSDVSTAG TGASRSSHSSDSGGSDVDLDPTDGKLFPSDGFRDCKKGDPKHGKRKRGRP RKLSKEYWDCLEGKKSKHAPRGTHLWEFIRDILIHPELNEGLMKWENRHE GVFKFLRSEAVAQLWGQKKKNSNMTYEKLSRAMRYYYKREILERVDGRRL VYKFGKNSSGWKEEEVLQSRN
    • Molecular weight

      68 kDa including tags
    • Amino acids

      1 to 371

Associated products

Specifications

Our Abpromise guarantee covers the use of ab131849 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Western blot

    ELISA

  • Form

    Liquid
  • Additional notes

    Protein concentration is above or equal to 0.05 mg/ml.
    Best used within three months from the date of receipt.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names

    • E74 like factor 3
    • E74 like factor 3 ets domain transcription factor
    • E74 like factor 3 ets domain transcription factor epithelial specific
    • E74 like factor 3 ETS domain transcription factor serine box epithelial specific
    • E74-like factor 3
    • Elf3
    • ELF3_HUMAN
    • Epithelial restricted with serine box
    • Epithelial-restricted with serine box
    • Epithelium restricted Ets protein ESX
    • Epithelium specific Ets factor 1
    • Epithelium specific Ets transcription factor 1
    • Epithelium-restricted Ets protein ESX
    • Epithelium-specific Ets transcription factor 1
    • EPR 1
    • EPR1
    • ERT
    • ESE-1
    • ESX
    • Ets domain transcription factor serine box
    • Ets domain transcription factor serine box epithelial specific
    • Ets transcription factor
    • ETS-related transcription factor Elf-3
    • jen
    • MGC139318
    see all
  • Function

    Transcriptional activator that binds and transactivates ETS sequences containing the consensus nucleotide core sequence GGA[AT]. Acts synergistically with POU2F3 to transactivate the SPRR2A promoter and with RUNX1 to transactivate the ANGPT1 promoter. Also transactivates collagenase, CCL20, CLND7, FLG, KRT8, NOS2, PTGS2, SPRR2B, TGFBR2 and TGM3 promoters. Represses KRT4 promoter activity. Involved in mediating vascular inflammation. May play an important role in epithelial cell differentiation and tumorigenesis. May be a critical downstream effector of the ERBB2 signaling pathway. May be associated with mammary gland development and involution. Plays an important role in the regulation of transcription with TATA-less promoters in preimplantation embryos, which is essential in preimplantation development.
  • Tissue specificity

    Expressed exclusively in tissues containing a high content of terminally differentiated epithelial cells including mammary gland, colon, trachea, kidney, prostate, uterus, stomach and skin.
  • Sequence similarities

    Belongs to the ETS family.
    Contains 1 ETS DNA-binding domain.
    Contains 1 PNT (pointed) domain.
  • Domain

    the 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
  • Cellular localization

    Cytoplasm. Nucleus. Localizes to the cytoplasm where it has been shown to transform MCF-12A mammary epithelial cells via a novel cytoplasmic mechanism. Also transiently expressed and localized to the nucleus where it induces apoptosis in non-transformed breast epithelial cells MCF-10A and MCF-12A via a transcription-dependent mechanism.
  • Information by UniProt

Images

  • 12.5% SDS-PAGE analysis of ab131849 stained with Coomassie Blue.

References

ab131849 has not yet been referenced specifically in any publications.

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