Overview

  • Product name

    Recombinant Human EWI-2 protein (His tag)
  • Protein length

    Protein fragment

Description

  • Nature

    Recombinant
  • Source

    Baculovirus infected insect cells
  • Amino Acid Sequence
    • Accession
    • Species

      Human
    • Sequence

      ADLREVLVPEGPLYRVAGTAVSISCNVTGYEGPAQQNFEWFLYRPEAPDT ALGIVSTKDTQFSYAVFKSRVVAGEVQVQRLQGDAVVLKIARLQAQDAGI YECHTPSTDTRYLGSYSGKVELRVLPDVLQVSAAPPGPRGRQAPTSPPRM TVHEGQELALGCLARTSTQKHTHLAVSFGRSVPEAPVGRSTLQEVVGIRS DLAVEAGAPYAERLAAGELRLGKEGTDRYRMVVGGAQAGDAGTYHCTAAE WIQDPDGSWAQIAEKRAVLAHVDVQTLSSQLAVTVGPGERRIGPGEPLEL LCNVSGALPPAGRHAAYSVGWEMAPAGAPGPGRLVAQLDTEGVGSLGPGY EGRHIAMEKVASRTYRLRLEAARPGDAGTYRCLAKAYVRGSGTRLREAAS ARSRPLPVHVREEGVVLEAVAWLAGGTVYRGETASLLCNISVRGGPPGLR LAASWWVERPEDGELSSVPAQLVGGVGQDGVAELGVRPGGGPVSVELVGP RSHRLRLHSLGPEDEGVYHCAPSAWVQHADYSWYQAGSARSGPVTVYPYM HALDTHHHHHH
    • Molecular weight

      60 kDa including tags
    • Amino acids

      28 to 579
    • Tags

      His tag C-Terminus

Specifications

Our Abpromise guarantee covers the use of ab222989 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Endotoxin level

    < 1.000 Eu/µg
  • Purity

    > 95 % SDS-PAGE.
    Purified by using conventional chromatography techniques.
  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 7.4
    Constituents: 30% Glycerol, PBS

General Info

  • Alternative names

    • CD316
    • CD316 antigen
    • CD81 partner 3
    • CD81P3
    • EWI-2
    • EWI2
    • Glu-Trp-Ile EWI motif-containing protein 2
    • igsf-8
    • IgSF8
    • IGSF8_HUMAN
    • Immunoglobulin superfamily member 8
    • Immunoglobulin superfamily member 8 precursor
    • KCT-4
    • KCT4
    • Keratinocytes-associated transmembrane protein 4
    • LIR-D1
    • PGRL
    • Prostaglandin regulatory-like protein
    see all
  • Function

    May play a key role in diverse functions ascribed to CD81 and CD9 such as oocytes fertilization or hepatitis C virus function. May regulate proliferation and differentiation of keratinocytes. May be a negative regulator of cell motility: suppresses T-cell mobility coordinately with CD81, associates with CD82 to suppress prostate cancer cell migration, regulates epidermoid cell reaggregation and motility on laminin-5 with CD9 and CD81 as key linkers. May also play a role on integrin-dependent morphology and motility functions. May participate in the regulation of neurite outgrowth and maintenance of the neural network in the adult brain.
  • Tissue specificity

    Expressed in brain, kidney, testis, liver and placenta with moderate expression in all other tissues. Detected on a majority of B-cells, T-cells, and natural killer cells but not on monocytes, polynuclear cells and platelets.
  • Sequence similarities

    Contains 4 Ig-like C2-type (immunoglobulin-like) domains.
  • Domain

    The Ig-like C2-type domains 3 and 4 are required for interaction with CD81.
    The short cytoplasmic domain is very basic, interacts with membrane PIPs, and mediates plasma membrane localization.
  • Cellular localization

    Cell membrane.
  • Information by UniProt

Images

  • 3 μg ab222989 analyzed by 15% SDS-PAGE.

References

ab222989 has not yet been referenced specifically in any publications.

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