The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Protein concentration is above or equal to 0.05 mg/ml.
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Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.31% Glutathione, 0.79% Tris HCl
EGF-like protein 10
EGF-like protein 11
EGF-like-domain, multiple 10
EGF-like-domain, multiple 11
Epidermal growth factor-like protein 10
Epidermal growth factor-like protein 11
Eyes shut homolog (Drosophila)
Protein eyes shut homolog
Protein spacemaker homolog
Required to maintain the integrity of photoreceptor cells.
Present in retina.
Involvement in disease
Defects in EYS are the cause of retinitis pigmentosa type 25 (RP25) [MIM:602772]. RP leads to degeneration of retinal photoreceptor cells. Patients suffer from night blindness, beginning at approximately 25 years of age, and deterioration of visual acuity (central vision), beginning at approximately 30 years of age. By age 55 to 60 years, many affected subjects have no perception of light in either eye.
Belongs to the EYS family. Contains 27 EGF-like domains. Contains 5 laminin G-like domains.
Secreted. Localizes in the photoreceptor cell layer.