Overview

Description

  • Nature

    Recombinant
  • Source

    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species

      Human
    • Sequence

      MCDAFVGTWK LVSSENFDDY MKEVGVGFAT RKVAGMAKPN MIISVNGDVI TIKSESTFKN TEISFILGQE FDEVTADDRK VKSTITLDGG VLVHVQKWDG KSTTIKRKRE DDKLVVECVM KGVTSTRVYE RA
    • Molecular weight

      15 kDa
    • Amino acids

      1 to 132

Specifications

Our Abpromise guarantee covers the use of ab133145 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    Immunoprecipitation

    ELISA

  • Purity

    > 95 % SDS-PAGE.

  • Form

    Lyophilised
  • Additional notes

    Product is not sterile, filter before use in cell culture.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Constituent: 99% PBS

  • Reconstitution
    Add deionized water to prepare a working stock solution of approximately 1 mg/mL and let the lyophilized pellet dissolve completely.

General Info

  • Alternative names

    • 3T3-L1 lipid-binding protein
    • 422/aP2
    • A-FABP
    • adipocyte
    • Adipocyte lipid binding protein
    • Adipocyte lipid-binding protein
    • Adipocyte protein AP2
    • Adipocyte-type fatty acid-binding protein
    • AFABP
    • ALBP
    • ALBP/Ap2
    • aP2
    • Epididymis secretory protein Li 104
    • FABP
    • FABP4
    • FABP4_HUMAN
    • Fatty acid binding protein 4
    • Fatty acid binding protein 4 adipocyte
    • Fatty acid binding protein adipocyte
    • Fatty acid-binding protein
    • Fatty acid-binding protein 4
    • HEL S 104
    • Lbpl
    • Myelin P2 protein homolog
    • P15
    • P2 adipocyte protein
    • Protein 422
    see all
  • Function

    Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus.
  • Sequence similarities

    Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
  • Domain

    Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.
  • Cellular localization

    Cytoplasm. Nucleus. Depending on the nature of the ligand, a conformation change exposes a nuclear localization motif and the protein is transported into the nucleus. Subject to constitutive nuclear export.
  • Information by UniProt

References

This product has been referenced in:

  • Shrestha S  et al. Circulating FABP4 is eliminated by the kidney via glomerular filtration followed by megalin-mediated reabsorption. Sci Rep 8:16451 (2018). Read more (PubMed: 30401801) »
See 1 Publication for this product

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