Overview

Description

  • Nature

    Recombinant
  • Source

    Insect cells
  • Amino Acid Sequence
    • Accession
    • Species

      Human
    • Sequence

      PPRGRILGGR EAEAHARPYM ASVQLNGAHL CGGVLVAEQW VLSAAHCLED AADGKVQVLL GAHSLSQPEP SKRLYDVLRA VPHPDSQPDT IDHDLLLLQL SEKATLGPAV RPLPWQRVDR DVAPGTLCDV AGWGIVNHAG RRPDSLQHVL LPVLDRATCN RRTHHDGAIT ERLMCAESNR RDSCKGDSGG PLVCGGVLEG VVTSGSRVCG NRKKPGIYTR VASYAAWIDS VLAVEHHHHH H
    • Molecular weight

      26 kDa including tags
    • Amino acids

      21 to 253
    • Tags

      His tag C-Terminus
    • Additional sequence information

      Full length mature form without signal peptide, with propeptide. NCBI Accession No.: NP_001919.

Specifications

Our Abpromise guarantee covers the use of ab202242 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Mass Spectrometry

    SDS-PAGE

  • Endotoxin level

    < 1.000 Eu/µg
  • Mass spectrometry

    MALDI-TOF
  • Purity

    > 95 % SDS-PAGE.
    ab202242 was purified by conventional chromatography techniques.
  • Additional notes

     This product was previously labelled as Factor D

     

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

General Info

  • Alternative names

    • Adipsin
    • Adipsin/complement factor D
    • Adn
    • C3 convertase activator
    • CFAD_HUMAN
    • CFD
    • Complement factor D
    • complement factor D preproprotein
    • D component of complement
    • DF
    • FactorD
    • PFD
    • Properdin factor D
    see all
  • Function

    Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway.
  • Involvement in disease

    Defects in CFD are the cause of complement factor D deficiency (CFD deficiency) [MIM:134350]. CFD deficiency predisposes to invasive meningococcal disease.
  • Sequence similarities

    Belongs to the peptidase S1 family.
    Contains 1 peptidase S1 domain.
  • Cellular localization

    Secreted.
  • Information by UniProt

Images

  • 15% SDS-PAGE analysis of ab202242 (3 µg)

References

ab202242 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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