Product nameRecombinant Human Factor V protein
See all Factor V proteins and peptides
Protein lengthProtein fragment
Amino Acid Sequence
Amino acids29 to 128
Tagsproprietary tag N-Terminus
Our Abpromise guarantee covers the use of ab158400 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Additional notesProtein concentration is above or equal to 0.05 mg/ml.
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Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
Constituents: 0.31% Glutathione, 0.79% Tris HCl
- Activated protein C cofactor
- APC cofactor
- Coagulation factor V
FunctionCentral regulator of hemostasis. It serves as a critical cofactor for the prothrombinase activity of factor Xa that results in the activation of prothrombin to thrombin.
Involvement in diseaseFactor V deficiency
Thrombophilia due to activated protein C resistance
Pregnancy loss, recurrent, 1
Sequence similaritiesBelongs to the multicopper oxidase family.
Contains 3 F5/8 type A domains.
Contains 2 F5/8 type C domains.
Contains 6 plastocyanin-like domains.
DomainDomain B contains 35 x 9 AA tandem repeats, and 2 x 17 AA repeats.
modificationsThrombin activates factor V proteolytically to the active cofactor, factor Va (formation of a heavy chain at the N-terminus and a light chain at the C-terminus).
Sulfation is required for efficient thrombin cleavage and activation and for full procoagulant activity.
Activated protein C inactivates factor V and factor Va by proteolytic degradation.
Phosphorylation sites are present in the extracellular medium.
- Information by UniProt
ab158400 has not yet been referenced specifically in any publications.