Description

  • Product name

    Recombinant Human FAM38A/PIEZO1 protein
    See all FAM38A/PIEZO1 proteins and peptides
  • Expression system

    Wheat germ
  • Accession

  • Protein length

    Full length protein
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Human
    • Sequence

      MKICPFSSKSSIVLALKFRSLIHFEKYPQPKGQKKKKIVKYGMGGLIILF LIAIIWFPLLFMSLVRSVVGVVNQPIDVTVTLKLGGYEPLFTMSAQQPSI IPFTAQAYEELSRQFDPQPLAMQFISQYSPEDIVTAQIEGSSGALWRISP PSRAQMKRELYNGTADITLRFTWNFQRDLAKGGTVEYANEKHMLALAPNS TARRQLASLLEGTSDQSVVIPNLFPKYIRAPNGPEANPVKQLQPNEEADY LGVRIQLRREQGAGATGFLEWWVIELQECRTDCNLLPMVIFSDKHHGAVR VHRAGHRQVRARILQRDLALHYVRGAAVRGPHPQALPGHLPGAGDSGAGA GGGVVCQAHLPLPLTGDHDQVDS
    • Predicted molecular weight

      67 kDa including tags
    • Amino acids

      1 to 373

Specifications

Our Abpromise guarantee covers the use of ab132881 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    ELISA

    SDS-PAGE

  • Form

    Liquid
  • Additional notes

    Protein concentration is above or equal to 0.05 µg/µl.

     This product was previously labelled as FAM38A

     

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names

    • DHS
    • Fam38a
    • Family with sequence similarity 38 member A
    • KIAA0233
    • Membrane protein induced by beta-amyloid treatment
    • Mib
    • PIEZ1_HUMAN
    • Piezo-type mechanosensitive ion channel component 1
    • PIEZO1
    • Protein FAM38A
    • Protein FAM38B
    • Protein PIEZO1
    see all
  • Function

    Component of mechanosensitive channel required for the mechanosensitive currents. Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling.
  • Tissue specificity

    Expressed in numerous tissues. In normal brain, expressed exclusively in neurons, not in astrocytes. In Alzheimer disease brains, expressed in about half of the activated astrocytes located around classical senile plaques. In Parkinson disease substantia nigra, not detected in melanin-containing neurons nor in activated astrocytes.
  • Sequence similarities

    Belongs to the PIEZO family.
  • Cellular localization

    Endoplasmic reticulum membrane. Endoplasmic reticulum-Golgi intermediate compartment membrane. Cell membrane.
  • Information by UniProt

Images

  • 12.5% SDS-PAGE analysis of ab132881 stained with Coomassie Blue.

References

ab132881 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab132881.
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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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