The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Measured by its ability to induce apoptosis of Jurkat Human acute T cell leukemia cells.
The ED50 for this effect is typically 0.1-1.5 ng/ml in the presence of 10 µg/ml of a crosslinking antibody Mouse Anti poly-Histidine Monoclonal Antibody.
< 1.000 Eu/µg
>95% by SDS-PAGE .
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Store at +4°C.
pH: 7.40 Constituents: 95% PBS, 5% Trehalose
This product is an active protein and may elicit a biological response in vivo, handle with caution.
It is recommended to reconstitute the lyophilized protein in sterile deionized water to a final concentration of 400 ug/ml. Solubilize for 30 to 60 minutes at room temperature with occasional gentle mixing. Carrier protein (0.1% HSA or BSA) is strongly recommended for further dilution and long term storage.
Apoptosis (APO 1) antigen ligand 1
Apoptosis antigen ligand
Apoptosis antigen ligand 1
Fas antigen ligand
Fas ligand (TNF superfamily member 6)
Fasl Fas ligand (TNF superfamily member 6)
Generalized lymphoproliferative disease
Tumor necrosis factor (ligand) superfamily member 6
Tumor necrosis factor ligand superfamily member 6
Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. May be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects.
Involvement in disease
Defects in FASLG are the cause of autoimmune lymphoproliferative syndrome type 1B (ALPS1B) [MIM:601859]; also known as Canale-Smith syndrome (CSS). ALPS is a childhood syndrome involving hemolytic anemia and thrombocytopenia with massive lymphadenopathy and splenomegaly.
Belongs to the tumor necrosis factor family.
N-glycosylated. The soluble form derives from the membrane form by proteolytic processing.
Cell membrane. Secreted. May be released into the extracellular fluid, probably by cleavage form the cell surface.