Overview

Description

  • Nature

    Recombinant
  • Source

    Baculovirus infected Sf9 cells
  • Amino Acid Sequence
    • Accession
    • Species

      Human
    • Molecular weight

      84 kDa including tags
    • Amino acids

      1 to 549

Associated products

Specifications

Our Abpromise guarantee covers the use of ab131693 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Functional Studies

    SDS-PAGE

    Western blot

  • Purity

    > 70 % SDS-PAGE.
    Assessed by densitometry.
  • Form

    Liquid
  • Additional notes

    ab204874 (PKI-alpha peptide) can be utilized as a substrate for assessing kinase activity

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 7.50
    Constituents: 0.31% Glutathione, 0.002% PMSF, 0.005% DTT, 0.79% Tris HCl, 0.003% EDTA, 25% Glycerol, 0.88% Sodium chloride

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names

    • Fas activated serine threonine kinase
    • Fas-activated serine/threonine kinase
    • FAST
    • FAST kinase
    • FASTK
    • FASTK_HUMAN
    • FLJ13079
    see all
  • Function

    Phosphorylates the splicing regulator TIA1, thereby promoting the inclusion of FAS exon 6, which leads to an mRNA encoding a pro-apoptotic form of the receptor.
  • Tissue specificity

    Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
  • Sequence similarities

    Belongs to the FAST protein kinase family.
    Contains 1 RAP domain.
  • Post-translational
    modifications

    Autophosphorylated on serine/threonine residues. Activated by dephosphorylation.
  • Information by UniProt

Images

  • The specific activity of ab131693 was determined to be 1.0 nmol/min/mg.
  • The purity of ab131693 was determined to be >70% by densitometry.

References

ab131693 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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