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    recombinant-human-fbp2-protein-ab208316.pdf

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Recombinant human FBP2 protein (ab208316)

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SDS-PAGE - Recombinant human FBP2 protein (ab208316)

    Key features and details

    • Expression system: Escherichia coli
    • Purity: > 90% SDS-PAGE
    • Active: Yes
    • Tags: His tag N-Terminus
    • Suitable for: SDS-PAGE, Functional Studies, MS

    Description

    • Product name

      Recombinant human FBP2 protein
      See all FBP2 proteins and peptides
    • Biological activity

      Specific activity is > 1,500 pmol/min/ug obtained by measuring the increase of NADPH in absorbance at 340 nm resulting from the reduction of NADP. One unit will oxidize 1.0 pmole of fructose 1,6 diphosphate to fructose 6-phosphate and inorganic phosphate per minute at pH 9.5 at 37C.

    • Purity

      > 90 % SDS-PAGE.
      ab208316 was purified using conventional chromatography techniques.
    • Expression system

      Escherichia coli
    • Accession

      O00757
    • Protein length

      Full length protein
    • Animal free

      No
    • Nature

      Recombinant
      • Species

        Human
      • Sequence

        MGSSHHHHHHSSGLVPRGSHMGSMTDRSPFETDMLTLTRYVMEKGRQAKG TGELTQLLNSMLTAIKAISSAVRKAGLAHLYGIAGSVNVTGDEVKKLDVL SNSLVINMVQSSYSTCVLVSEENKDAIITAKEKRGKYVVCFDPLDGSSNI DCLASIGTIFAIYRKTSEDEPSEKDALQCGRNIVAAGYALYGSATLVALS TGQGVDLFMLDPALGEFVLVEKDVKIKKKGKIYSLNEGYAKYFDAATTEY VQKKKFPEDGSAPYGARYVGSMVADVHRTLVYGGIFLYPANQKSPKGKLR LLYECNPVAYIIEQAGGLATTGTQPVLDVKPEAIHQRVPLILGSPEDVQE YLTCVQKNQAGS
      • Predicted molecular weight

        39 kDa including tags
      • Amino acids

        1 to 339
      • Tags

        His tag N-Terminus
      • Additional sequence information

        NP_003828.

    Associated products

    • Related Products

      • Anti-FBP2 antibody [EPR7436] (ab131253)
      • Anti-FBP2 antibody [EPR7435] (ab131333)
      • Anti-6X His tag® antibody [HIS.H8] (ab18184)
      • Anti-6X His tag® antibody [4D11] (ab5000)
      • Anti-6X His tag® antibody (ab9108)

    Specifications

    Our Abpromise guarantee covers the use of ab208316 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • Applications

      SDS-PAGE

      Functional Studies

      Mass Spectrometry

    • Mass spectrometry

      MALDI-TOF
    • Form

      Liquid
    • Concentration information loading...

    Preparation and Storage

    • Stability and Storage

      Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

      pH: 8.00
      Constituents: 0.32% Tris HCl, 0.87% Sodium chloride, 10% Glycerol (glycerin, glycerine), 0.02% DTT

      This product is an active protein and may elicit a biological response in vivo, handle with caution.

    General Info

    • Alternative names

      • 6-bisphosphatase isozyme 2
      • 6-bisphosphate 1-phosphohydrolase 2
      • D fructose 1 6 bisphosphate 1 phosphohydrolase 2
      • D-fructose-1
      • F16P2_HUMAN
      • FBP 2
      • fbp2
      • FBPase
      • FBPase 2
      • fructose 1 6 bisphosphatase 2
      • Fructose 1 6 bisphosphatase isozyme 2
      • Fructose-1
      • Hexosediphosphatase
      • MGC142192
      • Muscle FBPase
      • Muscle fructose bisphosphatase
      see all
    • Function

      Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations and probably participates in glycogen synthesis from carbohydrate precursors, such as lactate.
    • Tissue specificity

      Expressed in skeletal muscle (at protein level).
    • Pathway

      Carbohydrate biosynthesis; gluconeogenesis.
    • Sequence similarities

      Belongs to the FBPase class 1 family.
    • Cellular localization

      Cell junction. Cytoplasm. Nucleus. Cytoplasm, myofibril, sarcomere, Z line. In neonatal cardiomyocytes, distributed throughout the cytosol, accumulating in the intercalated disks which occur at the Z line of cardiomyocytes and connect adjacent cells, and also located in the nucleus; dissociates from the Z line following an increase in cytosolic Ca(2+) concentration (By similarity). In muscle precursor cells, localizes predominantly to the nucleus and to a lesser extent to the cytoplasm at the proliferative phase, while mainly localizing to the cytoplasm at the differentiation phase (By similarity). Colocalizes with ALDOA and alpha-actinin on both sides of the Z line of skeletal muscle; dissociates rapidly from the Z line following an increase in cytosolic Ca(2+) concentration.
    • Target information above from: UniProt accession O00757 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt

    Images

    • SDS-PAGE - Recombinant human FBP2 protein (ab208316)
      SDS-PAGE - Recombinant human FBP2 protein (ab208316)

      15% SDS-PAGE analysis of ab208316 (3µg).

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    Datasheets and documents

    • Datasheet
  • References (0)

    Publishing research using ab208316? Please let us know so that we can cite the reference in this datasheet.

    ab208316 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

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