Description

  • Product name

    Recombinant Human FBXO2 protein
  • Purity

    > 80 % SDS-PAGE.
    ab180282 is purified using conventional chromatography techniques
  • Expression system

    Escherichia coli
  • Accession

  • Protein length

    Full length protein
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Human
    • Sequence

      MGSSHHHHHH SSGLVPRGSH MGSMDGDGDP ESVGQPEEAS PEEQPEEASA EEERPEDQQE EEAAAAAAYL DELPEPLLLR VLAALPAAEL VQACRLVCLR WKELVDGAPL WLLKCQQEGL VPEGGVEEER DHWQQFYFLS KRRRNLLRNP CGEEDLEGWC DVEHGGDGWR VEELPGDSGV EFTHDESVKK YFASSFEWCR KAQVIDLQAE GYWEELLDTT QPAIVVKDWY SGRSDAGCLY ELTVKLLSEH ENVLAEFSSG QVAVPQDSDG GGWMEISHTF TDYGPGVRFV RFEHGGQDSV YWKGWFGARV TNSSVWVEP
    • Predicted molecular weight

      36 kDa including tags
    • Amino acids

      1 to 296
    • Tags

      His tag N-Terminus
    • Additional sequence information

      NP_036300.

Specifications

Our Abpromise guarantee covers the use of ab180282 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Mass Spectrometry

    SDS-PAGE

  • Mass spectrometry

    MALDI-TOF
  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 0.32% Tris HCl, 30% Glycerol, 0.88% Sodium chloride, 0.02% DTT

General Info

  • Alternative names

    • F box gene 1
    • F box only protein 2
    • F box protein 2
    • F box protein only 2
    • F-box only protein 2
    • FBG 1
    • FBG1
    • Fbs 1
    • Fbs1
    • Fbs2
    • FBX 2
    • FBX2
    • FBX2_HUMAN
    • FBXO 2
    • FBXO2
    • Neural F box protein NFB42
    • Neural F-box protein, 42-KD, rat, homolog of
    • NFB 42
    • NFB42
    • OCP1
    • organ of Corti protein 1
    • Prpl4
    see all
  • Function

    Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Involved in the endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Prevents formation of cytosolic aggregates of unfolded glycoproteins that have been retrotranslocated into the cytosol. Able to recognize and bind denatured glycoproteins, preferentially those of the high-mannose type.
  • Pathway

    Protein modification; protein ubiquitination.
  • Sequence similarities

    Contains 1 F-box domain.
    Contains 1 FBA (F-box associated) domain.
  • Cellular localization

    Cytoplasm. Microsome membrane.
  • Information by UniProt

Images

  • 15% SDS-PAGE analysis of ab180282 (3μg).

References

ab180282 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab180282.
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