The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Protein concentration is above or equal to 0.05 mg/ml.
Concentration information loading...
Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.31% Glutathione, 0.79% Tris HCl
Archipelago, Drosophila, homolog of
CDC4, S.cerevisiae, homolog of
F box and WD 40 domain protein 7
F box and WD 40 domain protein 7 (archipelago homolog, Drosophila)
F box and WD repeat domain containing 7
F box protein FBW7
F box protein FBX30
F box protein SEL 10
F box protein SEL10
F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
F-box and WD-40 domain-containing protein 7
F-box protein FBX30
F-box/WD repeat-containing protein 7
Homolog of C elegans sel 10
Homolog of C.elegans sel10
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. Involved in the degradation of cyclin-E, MYC, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1.
Isoform 1 is widely expressed. Isoform 4 is expressed in brain.
Contains 1 F-box domain. Contains 7 WD repeats.
Phosphorylated upon DNA damage, probably by ATM or ATR.
Cytoplasm; Nucleus; Nucleus > nucleolus and Nucleus > nucleoplasm.