Recombinant Human FECH protein (ab158429)
- Datasheet
- References
- Protocols
Overview
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Product nameRecombinant Human FECH protein
See all FECH proteins and peptides -
Protein lengthFull length protein
Description
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NatureRecombinant
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SourceWheat germ
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Amino Acid Sequence
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SpeciesHuman
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SequenceMRSLGANMAAALRAAGVLLRDPLASSSWRVCQPWRWKSGAAAAAVTTETA QHAQGAKPQVQPQKRKPKTGILMLNMGGPETLGDVHDFLLRLFLDQDLMT LPIQNKLAPFIAKRRTPKIQEQYRRIGGGSPIKIWTSKQGEGMVKLLDEL SPNTAPHKYYIGFRYVHPLTEEAIEEMERDGLERAIAFTQYPQYSCSTTG SSLNAIYRYYNQVGRKPTMKWSTIDRWPTHHLLIQCFADHILKELDHFPL EKRSEVVILFSAHSLPMSVVNRGDPYPQEVSATVQKVMERLEYCNPYRLV WQSKVGPMPWLGPQTDESIKGLCERGRKNILLVPIAFTSDHIETLYELDI EYSQVLAKECGVENIRRAESLNGNPLFSKALADLVHSHIQSNELCSKQLT LSCPLCVNPVCRETKSFFTSQQL
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Amino acids1 to 423
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Tagsproprietary tag N-Terminus
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Specifications
Our Abpromise guarantee covers the use of ab158429 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Applications
Western blot
ELISA
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FormLiquid
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Additional notesProtein concentration is above or equal to 0.05 mg/ml.
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Concentration information loading...
Preparation and Storage
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Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00
Constituents: 0.31% Glutathione, 0.79% Tris HCl
General Info
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Alternative names
- EPP
- FCE
- Fch
see all -
FunctionCatalyzes the ferrous insertion into protoporphyrin IX.
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PathwayPorphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1.
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Involvement in diseaseErythropoietic protoporphyria (EPP) [MIM:177000]: A form of porphyria. Porphyrias are inherited defects in the biosynthesis of heme, resulting in the accumulation and increased excretion of porphyrins or porphyrin precursors. They are classified as erythropoietic or hepatic, depending on whether the enzyme deficiency occurs in red blood cells or in the liver. Erythropoietic protoporphyria is marked by excessive protoporphyrin in erythrocytes, plasma, liver and feces, and by widely varying photosensitive skin changes ranging from a burning or pruritic sensation to erythema, edema and wheals. Note=The disease is caused by mutations affecting the gene represented in this entry.
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Sequence similaritiesBelongs to the ferrochelatase family.
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Cellular localizationMitochondrion inner membrane.
- Information by UniProt
Images
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SDS-PAGE - Recombinant Human FECH protein (ab158429)ab158429 on a 12.5% SDS-PAGE stained with Coomassie Blue.
Datasheets and documents
References
ab158429 has not yet been referenced specifically in any publications.
