Recombinant Human FECH protein (ab158429)

Our Abpromise guarantee covers the use of ab158429 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Alternative names
- EPP
- FCE
- Fch
- Fcl
- fech
- Ferrochelatase
- Ferrochelatase (protoporphyria)
- Ferrochelatase mitochondrial
- Heme synthase
- Heme synthetase
- HEMH_HUMAN
- mitochondrial
- Protoheme ferro lyase
- Protoheme ferro-lyase
- Protoporphyria
see all
Function

Catalyzes the ferrous insertion into protoporphyrin IX.
Pathway

Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1.
Involvement in disease

Erythropoietic protoporphyria (EPP) [MIM:177000]: A form of porphyria. Porphyrias are inherited defects in the biosynthesis of heme, resulting in the accumulation and increased excretion of porphyrins or porphyrin precursors. They are classified as erythropoietic or hepatic, depending on whether the enzyme deficiency occurs in red blood cells or in the liver. Erythropoietic protoporphyria is marked by excessive protoporphyrin in erythrocytes, plasma, liver and feces, and by widely varying photosensitive skin changes ranging from a burning or pruritic sensation to erythema, edema and wheals. Note=The disease is caused by mutations affecting the gene represented in this entry.
Sequence similarities

Belongs to the ferrochelatase family.
Cellular localization

Mitochondrion inner membrane.
Target information above from: UniProt accession P22830 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt

SDS-PAGE - Recombinant Human FECH protein (ab158429)

ab158429 on a 12.5% SDS-PAGE stained with Coomassie Blue.

ab158429 has not yet been referenced specifically in any publications.

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