Recombinant human FGF19 protein (Animal Free) (ab224778)
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Description
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Product name
Recombinant human FGF19 protein (Animal Free)
See all FGF19 proteins and peptides -
Biological activity
Determined by a cell proliferation assay using Balb/c 3T3 cells. The expected ED50 for this effect is 100-150 ng/ml.
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Purity
>= 95 % SDS-PAGE.
>= 95 % by HPLC analysis. -
Expression system
Escherichia coli -
Accession
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Protein length
Full length protein -
Animal free
Yes -
Nature
Recombinant -
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Species
Human -
Sequence
MRPLAFSDAGPHVHYGWGDPIRLRHLYTSGPHGLSSCFLRIRADGVVDCA RGQSAHSLLEIKAVALRTVAIKGVHSVRYLCMGADGKMQGLLQYSEEDCA FEEEIRPDGYNVYRSEKHRLPVSLSSAKQRQLYKNRGFLPLSHFLPMLPM VPEEPEDLRGHLESDMFSSPLETDSMDPFGLVTGLEAVRSPSFEK -
Predicted molecular weight
22 kDa -
Amino acids
23 to 216 -
Additional sequence information
This product is the mature full length protein from aa 23 to 216. The last residue of the signal peptide (aa 23) is included.
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Associated products
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Related Products
Specifications
Our Abpromise guarantee covers the use of ab224778 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Applications
HPLC
Functional Studies
SDS-PAGE
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Form
Lyophilised -
Concentration information loading...
Preparation and Storage
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Stability and Storage
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
This product is an active protein and may elicit a biological response in vivo, handle with caution.
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ReconstitutionFor lot specific reconstitution information please contact our Scientific Support Team.
General Info
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Alternative names
- FGF 19
- FGF-19
- FGF15
see all -
Function
Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. Activity requires the presence of KLB. -
Tissue specificity
Expressed in fetal brain, cartilage, retina, and adult gall bladder. -
Sequence similarities
Belongs to the heparin-binding growth factors family. -
Cellular localization
Secreted. - Information by UniProt
Datasheets and documents
References
ab224778 has not yet been referenced specifically in any publications.