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Recombinant human FGFR2 protein (ab89755)

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Functional Studies - Recombinant human FGFR2 protein (ab89755)
  • SDS-PAGE - Recombinant human FGFR2 protein (ab89755)
  • SDS-PAGE - Recombinant human FGFR2 protein (ab89755)
  • SDS-PAGE - Recombinant human FGFR2 protein (ab89755)
  • Functional Studies - Recombinant human FGFR2 protein (ab89755)

Key features and details

  • Expression system: Insect cells
  • Active: Yes
  • Suitable for: SDS-PAGE, WB, Functional Studies

Description

  • Product name

    Recombinant human FGFR2 protein
    See all FGFR2 proteins and peptides
  • Biological activity

    The Specific activity of ab89755 was determined to be 118 nmol/min/mg.
  • Expression system

    Insect cells
  • Protein length

    Protein fragment
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Human
    • Amino acids

      285 to 821

Associated products

  • Related Products

    • Anti-FGFR2 antibody (ab10647)
    • Anti-FGFR2 antibody (ab10648)
    • Anti-FGFR2 antibody [1G3] (ab58201)
    • Anti-FGFR2 antibody (ab77406)
  • Substrate reagent

    • Active Poly (Glu, Tyr) peptide (ab204877)

Specifications

Our Abpromise guarantee covers the use of ab89755 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Western blot

    Functional Studies

  • Form

    Liquid
  • Additional notes

    ab204877 (Poly (4:1 Glu, Tyr) peptide) can be utilized as a substrate for assessing kinase activity

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 7.50
    Constituents: 0.0038% EGTA, 0.00174% PMSF, 0.00385% DTT, 0.79% Tris HCl, 0.00292% EDTA, 25% Glycerol (glycerin, glycerine), 0.87% Sodium chloride

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names

    • bacteria-expressed kinase
    • BBDS
    • BEK
    • BEK fibroblast growth factor receptor
    • BFR1
    • CD332
    • CD332 antigen
    • CEK3
    • CFD1
    • Craniofacial dysostosis 1
    • ECT1
    • FGF receptor
    • FGFR 2
    • FGFR-2
    • Fgfr2
    • FGFR2_HUMAN
    • Fibroblast growth factor receptor 2
    • Hydroxyaryl protein kinase
    • Jackson Weiss syndrome
    • JWS
    • K SAM
    • K-sam
    • Keratinocyte growth factor receptor
    • Keratinocyte growth factor receptor 2
    • KGFR
    • KSAM
    • protein tyrosine kinase, receptor like 14
    • soluble FGFR4 variant 4
    • TK14
    • TK25
    see all
  • Function

    Receptor for acidic and basic fibroblast growth factors.
  • Involvement in disease

    Defects in FGFR2 are the cause of Crouzon syndrome (CS) [MIM:123500]; also called craniofacial dysostosis type I (CFD1). CS is an autosomal dominant syndrome characterized by craniosynostosis (premature fusion of the skull sutures), hypertelorism, exophthalmos and external strabismus, parrot-beaked nose, short upper lip, hypoplastic maxilla, and a relative mandibular prognathism.
    Defects in FGFR2 are a cause of Jackson-Weiss syndrome (JWS) [MIM:123150]. JWS is an autosomal dominant craniosynostosis syndrome characterized by craniofacial abnormalities and abnormality of the feet: broad great toes with medial deviation and tarsal-metatarsal coalescence.
    Defects in FGFR2 are a cause of Apert syndrome (APRS) [MIM:101200]; also known as acrocephalosyndactyly type 1 (ACS1). APRS is a syndrome characterized by facio-cranio-synostosis, osseous and membranous syndactyly of the four extremities, and midface hypoplasia. The craniosynostosis is bicoronal and results in acrocephaly of brachysphenocephalic type. Syndactyly of the fingers and toes may be total (mitten hands and sock feet) or partial affecting the second, third, and fourth digits. Intellectual deficit is frequent and often severe, usually being associated with cerebral malformations.
    Defects in FGFR2 are a cause of Pfeiffer syndrome (PS) [MIM:101600]; also known as acrocephalosyndactyly type V (ACS5). PS is characterized by craniosynostosis (premature fusion of the skull sutures) with deviation and enlargement of the thumbs and great toes, brachymesophalangy, with phalangeal ankylosis and a varying degree of soft tissue syndactyly. Three subtypes of Pfeiffer syndrome have been described: mild autosomal dominant form (type 1); cloverleaf skull, elbow ankylosis, early death, sporadic (type 2); craniosynostosis, early demise, sporadic (type 3).
    Defects in FGFR2 are the cause of Beare-Stevenson cutis gyrata syndrome (BSCGS) [MIM:123790]. BSCGS is an autosomal dominant condition is characterized by the furrowed skin disorder of cutis gyrata, acanthosis nigricans, craniosynostosis, craniofacial dysmorphism, digital anomalies, umbilical and anogenital abnormalities and early death.
    Defects in FGFR2 are the cause of familial scaphocephaly syndrome (FSPC) [MIM:609579]; also known as scaphocephaly with maxillary retrusion and mental retardation. FSPC is an autosomal dominant craniosynostosis syndrome characterized by scaphocephaly, macrocephaly, hypertelorism, maxillary retrusion, and mild intellectual disability. Scaphocephaly is the most common of the craniosynostosis conditions and is characterized by a long, narrow head. It is due to premature fusion of the sagittal suture or from external deformation.
    Defects in FGFR2 are a cause of lacrimo-auriculo-dento-digital syndrome (LADDS) [MIM:149730]; also known as Levy-Hollister syndrome. LADDS is a form of ectodermal dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. LADDS is an autosomal dominant syndrome characterized by aplastic/hypoplastic lacrimal and salivary glands and ducts, cup-shaped ears, hearing loss, hypodontia and enamel hypoplasia, and distal limb segments anomalies. In addition to these cardinal features, facial dysmorphism, malformations of the kidney and respiratory system and abnormal genitalia have been reported. Craniosynostosis and severe syndactyly are not observed.
    Defects in FGFR2 are the cause of Antley-Bixler syndrome (ABS) [MIM:207410]. ABS is a multiple congenital anomaly syndrome characterized by craniosynostosis, radiohumeral synostosis, midface hypoplasia, malformed ears, arachnodactyly and multiple joint contractures. ABS is a heterogeneous disorder and occurs with and without abnormal genitalia in both sexes.
  • Sequence similarities

    Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.
    Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
    Contains 1 protein kinase domain.
  • Cellular localization

    Secreted and Cell membrane.
  • Target information above from: UniProt accession P21802 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

Images

  • Functional Studies - Recombinant human FGFR2 protein (ab89755)
    Functional Studies - Recombinant human FGFR2 protein (ab89755)
    The specific activity of FGFR2 (ab89755) was determined to be 125 nmol/min/mg as per activity assay protocol
  • SDS-PAGE - Recombinant human FGFR2 protein (ab89755)
    SDS-PAGE - Recombinant human FGFR2 protein (ab89755)
    SDS PAGE analysis of ab89755
  • SDS-PAGE - Recombinant human FGFR2 protein (ab89755)
    SDS-PAGE - Recombinant human FGFR2 protein (ab89755)
    SDS PAGE analysis of ab89755
  • SDS-PAGE - Recombinant human FGFR2 protein (ab89755)
    SDS-PAGE - Recombinant human FGFR2 protein (ab89755)
    SDS-PAGE showing ab89755 at approximately 72kDa.
  • Functional Studies - Recombinant human FGFR2 protein (ab89755)
    Functional Studies - Recombinant human FGFR2 protein (ab89755)
    Kinase Assay demonstrating specific activity of ab89755.

Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

Datasheets and documents

  • SDS download

  • Datasheet download

    Download

References (0)

Publishing research using ab89755? Please let us know so that we can cite the reference in this datasheet.

ab89755 has not yet been referenced specifically in any publications.

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