Recombinant Human FGFR4 protein (His tag) (ab167751)

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Description

  • Product name

    Recombinant Human FGFR4 protein (His tag)
    See all FGFR4 proteins and peptides

  • Purity

    > 95 % SDS-PAGE.
    ab167751 is lyophilised from 0.22 µm filtered solution.

  • Endotoxin level

    < 1.000 Eu/µg

  • Expression system

    HEK 293 cells

  • Accession

    P22455

  • Protein length

    Protein fragment

  • Animal free

    No

  • Nature

    Recombinant

    • Species

      Human

    • Sequence

      LEASEEVELEPCLAPSLEQQEQELTVALGQPVRLCCGRAERGGHWYKEGS RLAPAGRVRGWRGRLEIASFLPEDAGRYLLARGSMIVLQNLTLITGDSLT SSNDDEDPKSHRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRC PAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTY TCLVENAVGSIRYNYLLDVLERSPHRPILQAGLPANTTAVVGSDVELLCK VYSDAQPHIQWLKHIVINGSSFGADGFPYVQVLKTADINSSEVEVLYLRN VSAEDAGEYTCLAGNSIGLSYQSAWLTVLPEEDPTWTAAAPEARYTD

    • Predicted molecular weight

      39 kDa including tags

    • Amino acids

      22 to 369

    • Tags

      His tag C-Terminus

Specifications

Our Abpromise guarantee covers the use of ab167751 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Form

    Lyophilised

  • Additional notes

    This product is stable after storage at:

    • -20°C to -70°C for 12 months in lyophilized state;
    • -70°C for 3 months under sterile conditions after reconstitution.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at Room Temperature. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 7.40
    Constituent: PBS

    5-10% trehalose is commonly used for freeze drying, and after reconstitution, the trehalose is mostly about 3-5%.

  • Reconstitution
    Reconstitute with sterile deionized water to a concentration of 100 µg/ml.

General Info

  • Alternative names

    • CD 334
    • CD334
    • CD334 antigen
    • fc13h 10
    • fc13h10
    • Fgfr 4
    • FGFR-4
    • Fgfr4
    • FGFR4_HUMAN
    • Fibroblast growth factor receptor 4
    • Hydroxyaryl protein kinase
    • JTK 2
    • JTK2
    • MGC20292
    • Protein tyrosine kinase
    • TKF
    • Tyrosine kinase related to fibroblast growth factor receptor
    • Tyrosylprotein kinase
    see all

  • Function

    Receptor for acidic fibroblast growth factor. Does not bind to basic fibroblast growth factor. Binds FGF19.

  • Tissue specificity

    Expressed in gastrointestinal epithelial cells, pancreas, and gastric and pancreatic cancer cell lines.

  • Sequence similarities

    Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.
    Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
    Contains 1 protein kinase domain.

  • Post-translational
    modifications

    Glycosylated.
    Phosphorylated on tyrosine residue (By similarity). Phosphorylation requires the presence of a functional (phosphorylated) FGFR1 and not necessarily by means of FGFR heterodimerization.

  • Cellular localization

    Membrane. Isoform 2 may be secreted.
  • Information by UniProt

Images

  • SDS-PAGE - Recombinant human FGFR4 protein (ab167751)
    SDS-PAGE - Recombinant human FGFR4 protein (ab167751)

    SDS-PAGE of reduced ab167751 stained overnight with Coomassie Blue. The protein migrates as 60 kDa due to glycosylation.

Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

References

Publishing research using ab167751? Please let us know so that we can cite the reference in this datasheet.

ab167751 has not yet been referenced specifically in any publications.

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