Overview

Description

  • Nature

    Recombinant
  • Source

    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species

      Human
    • Sequence

      MKHHHHHHAS MTTDEGAKNN EESPTATVAE QGEDITSKKD RGVLKIVKRV GNGEETPMIG DKVYVHYKGK LSNGKKFDSS HDRNEPFVFS LGKGQVIKAW DIGVATMKKG EICHLLCKPE YAYGSAGSLP KIPSNATLFF EIELLDFKGE DLFEDGGIIR RTKRKGEGYS NPNEGATVEI HLEGRCGGRM FDCRDVAFTV GEGEDHDIPI GIDKALEKMQ REEQCILYLG PRYGFGEAGK PKFGIEPNAE LIYEVTLKSF EKAKESWEMD TKEKLEQAAI VKEKGTVYFK GGKYMQAVIQ YGKIVSWLEM EYGLSEKESK ASESFLLAAF LNLAMCYLKL REYTKAVECC DKALGLDSAN EKGLYRRGEA QLLMNEFESA KGDFEKVLEV NPQNKAARLQ ISMCQKKAKE HNERDRRIYA NMFKKFAEQD AKEEANKAMG KKTSEGVTNE KGTDSQAMEE EKPEGHV
    • Molecular weight

      53 kDa including tags
    • Amino acids

      1 to 457
    • Tags

      His tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab206440 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Mass Spectrometry

    SDS-PAGE

  • Endotoxin level

    < 1.000 Eu/µg
  • Mass spectrometry

    LC-MS/MS
  • Purity

    > 90 % SDS-PAGE.

  • Form

    Lyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 7.50
    Constituents: 0.29% Sodium chloride, 0.32% Tris buffer

  • Reconstitution
    Add deionized water to prepare a working stock solution of approximately 0.5 mg/mL and let the lyophilized pellet dissolve completely. Filter sterilize your culture media/working solutions containing this non-sterile product before using in cell culture.

General Info

  • Alternative names

    • 51 kDa FK506 binding protein
    • 51 kDa FK506 binding protein 5
    • 51 kDa FK506-binding protein
    • 51 kDa FKBP
    • 54 kDa progesterone receptor associated immunophilin
    • 54 kDa progesterone receptor-associated immunophilin
    • AIG 6
    • AIG6
    • Androgen regulated protein 6
    • Androgen-regulated protein 6
    • FF1 antigen
    • FK506 binding protein 5
    • FK506-binding protein 5
    • FKBP 5
    • FKBP 51
    • FKBP 54
    • FKBP-5
    • FKBP-51
    • FKBP5
    • FKBP5_HUMAN
    • FKBP54
    • HSP90 binding immunophilin
    • HSP90-binding immunophilin
    • MGC111006
    • OTTHUMP00000016268
    • P54
    • Peptidyl prolyl cis trans isomerase
    • Peptidyl-prolyl cis-trans isomerase FKBP5
    • Peptidylprolyl cis trans isomerase
    • PPIase
    • PPIase FKBP5
    • Ptg 10
    • Ptg10
    • Rotamase
    • T cell FK506 binding protein
    see all
  • Function

    Interacts with functionally mature heterooligomeric progesterone receptor complexes along with HSP90 and TEBP.
  • Tissue specificity

    Widely expressed, enriched in testis compared to other tissues.
  • Sequence similarities

    Contains 2 PPIase FKBP-type domains.
    Contains 3 TPR repeats.
  • Post-translational
    modifications

    Phosphorylated upon DNA damage, probably by ATM or ATR.
  • Cellular localization

    Cytoplasm. Nucleus.
  • Information by UniProt

Images

  • 12 % SDS-PAGE separation of Human FKBP5.  

    MW Marker: 14, 21, 31, 45, 66, 97 kDa

    Lane 1: Reduced and boiled sample, 2.5 µg/lane

    Lane 2: Non-reduced and non-boiled sample, 2.5 µg/lane

References

ab206440 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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