The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Protein concentration is above or equal to 0.05 mg/ml
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Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.3% Glutathione, 0.79% Tris HCl
Brain factor 1
Brain factor 2
Forkhead box protein G1
Forkhead box protein G1A
Forkhead box protein G1B
Forkhead box protein G1C
Forkhead like 1
Forkhead like 2
Forkhead like 3
Forkhead like 4
Forkhead-related protein FKHL1
Forkhead-related protein FKHL2
Forkhead-related protein FKHL3
Transcription repression factor which plays an important role in the establishment of the regional subdivision of the developing brain and in the development of the telencephalon.
Expression is restricted to the neurons of the developing telencephalon.
Involvement in disease
Defects in FOXG1 are the cause of congenital variant of Rett syndrome (RTTCV) [MIM:613454]. RTTCV is a severe neurodevelopmental disorder with features of classic Rett syndrome but earlier onset in the first months of life. Clinical features include progressive microcephaly, hypotonia, irresponsiveness and irritability in the neonatal period, mental retardation, psychomotor regression and stereotypical movements.