Overview

Description

  • Nature

    Recombinant
  • Source

    Wheat germ
  • Amino Acid Sequence
    • Accession
    • Species

      Human
    • Sequence

      MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNY NNFHAAGGQGLTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDD LSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWY FGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHV KHYKIRKLDNGGYYITTRAQFETLQQLVQHYSGTWNGNTKVAIKTLKPGT MSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLK DGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICK IADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGIL LTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKK DPEERPTFEYLQSFLEDYFTATEPQYQPGENL
    • Molecular weight

      79 kDa including tags
    • Amino acids

      1 to 482

Specifications

Our Abpromise guarantee covers the use of ab152402 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    ELISA

    Western blot

    Functional Studies

  • Form

    Liquid
  • Additional notes

    Protein concentration is above or equal to 0.05 µg/µl.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names

    • C syn protooncogene
    • Fyn
    • FYN oncogene related to SRC FGR YES
    • FYN_HUMAN
    • OKT3 induced calcium influx regulator
    • P59 FYN
    • p59-Fyn
    • Protein tyrosine kinase fyn
    • Proto oncogene tyrosine protein kinase fyn
    • Proto-oncogene c-Fyn
    • Proto-oncogene Syn
    • Protooncogene Syn
    • SLK
    • Src like kinase
    • Src yes related novel gene
    • Src-like kinase
    • Src/yes related novel
    • SYN
    • Tyrosine kinase p59fyn T
    • Tyrosine kinase p59fyn(T)
    • Tyrosine-protein kinase Fyn
    see all
  • Function

    Tyrosine-protein kinase implicated in the control of cell growth. Plays a role in the regulation of intracellular calcium levels, with isoform 2 showing the greater ability to mobilize cytoplasmic calcium in comparison to isoform 1. Required in brain development and mature brain function with important roles in the regulation of axon growth, axon guidance, and neurite extension. Blocks axon outgrowth and attraction induced by NTN1 by phosphorylating its receptor DDC. Phosphorylates RUNX3.
  • Tissue specificity

    Isoform 1 is highly expressed in the brain. Isoform 2 is expressed in cells of hemopoietic lineages, especially T lymphocytes.
  • Sequence similarities

    Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
    Contains 1 protein kinase domain.
    Contains 1 SH2 domain.
    Contains 1 SH3 domain.
  • Cellular localization

    Cell membrane. Present and active in lipid rafts. Present in cell body and along the process of mature and developing oligodendroyctes.
  • Information by UniProt

Images

  • 12.5% SDS-PAGE analysis of ab152402 stained with Coomassie Blue.
  • Kinase Assay Using Radioisotope (Autoradiography).

References

ab152402 has not yet been referenced specifically in any publications.

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