Recombinant Human GALE protein (ab96767)

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Description

  • Product name

    Recombinant Human GALE protein
    See all GALE proteins and peptides

  • Purity

    > 95 % SDS-PAGE.
    ab96767 is purified using conventional chromatography techniques.

  • Expression system

    Escherichia coli

  • Accession

    Q14376

  • Protein length

    Full length protein

  • Animal free

    No

  • Nature

    Recombinant

    • Species

      Human

    • Sequence

      MGSSHHHHHHSSGLVPRGSHMAEKVLVTGGAGYIGSHTVLELLEAGYLPV VIDNFHNAFRGGGSLPESLRRVQELTGRSVEFEEMDILDQGALQRLFKKY SFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMKAHGVKNLVFS SSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADKTWNA VLLRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGNDY DTEDGTGVRDYIHVVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQM VQAMEKASGKKIPYKVVARREGDVAACYANPSLAQEELGWTAALGLDRMC EDLWRWQKQNPSGFGTQA

    • Predicted molecular weight

      40 kDa including tags

    • Amino acids

      1 to 348

    • Tags

      His tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab96767 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Mass Spectrometry

    SDS-PAGE

  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.077% DTT, 0.316% Tris HCl, 0.0292% EDTA, 10% Glycerol, 0.58% Sodium chloride

General Info

  • Alternative names

    • FLJ95174
    • FLJ97302
    • Galactose 4 epimerase UDP
    • Galactowaldenase
    • galE
    • GALE_HUMAN
    • OTTHUMP00000002991
    • OTTHUMP00000002994
    • OTTHUMP00000037931
    • OTTHUMP00000044857
    • SDR1E1
    • short chain dehydrogenase/reductase family 1E member 1
    • UDP galactose 4 epimerase
    • UDP galactose 4' epimerase
    • UDP glucose 4 epimerase
    • UDP-galactose 4-epimerase
    • UDP-glucose 4-epimerase
    see all

  • Function

    Catalyzes two distinct but analogous reactions: the epimerization of UDP-glucose to UDP-galactose and the epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine.

  • Pathway

    Carbohydrate metabolism; galactose metabolism.

  • Involvement in disease

    Defects in GALE are the cause of epimerase-deficiency galactosemia (EDG) [MIM:230350]; also known as galactosemia type 3. Clinical features include early-onset cataracts, liver damage, deafness and mental retardation. There are two clinically distinct forms of EDG. (1) A benign, or 'peripheral' form with no detectable GALE activity in red blood cells and characterized by mild symptoms. Some patients may suffer no symptoms beyond raised levels of galactose-1-phosphate in the blood. (2) A much rarer 'generalized' form with undetectable levels of GALE activity in all tissues and resulting in severe features such as restricted growth and mental development.

  • Sequence similarities

    Belongs to the sugar epimerase family.
  • Information by UniProt

Images

  • SDS-PAGE - Recombinant Human GALE protein (ab96767)
    SDS-PAGE - Recombinant Human GALE protein (ab96767)
    15% SDS-PAGE showing ab96767 at approximately 40.4kDa (3µg).

References

ab96767 has not yet been referenced specifically in any publications.

Publishing research using ab96767? Please let us know so that we can cite the reference in this datasheet.

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