Overview

  • Product name

    Recombinant Human gamma C Crystallin protein
  • Protein length

    Full length protein

Description

  • Nature

    Recombinant
  • Source

    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species

      Human
    • Sequence

      MGSSHHHHHH SSGLVPRGSH MGSHMGKITF YEDRAFQGRS YETTTDCPNL QPYFSRCNSI RVESGCWMLY ERPNYQGQQY LLRRGEYPDYQQWMGLSDSI RSCCLIPQTV SHRLRLYERE DHKGLMMELS EDCPSIQDRF HLSEIRSLHV LEGCWVLYEL PNYRGRQYLL RPQEYRRCQDWGAMDAKAGS LRRVVDLY
    • Molecular weight

      24 kDa including tags
    • Amino acids

      1 to 174
    • Tags

      His tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab126922 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Mass Spectrometry

  • Mass spectrometry

    MALDI-TOF
  • Purity

    > 95 % SDS-PAGE.
    ab126922 was purified using conventional chromatography techniques.
  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 0.03% DTT, 0.32% Tris HCl, 10% Glycerol, 1.17% Sodium chloride

General Info

  • Alternative names

    • CATARACT, VARIABLE ZONULAR PULVERULENT
    • CCL
    • CRGC_HUMAN
    • Cryg
    • CRYG 3
    • Cryg 5
    • CRYG3
    • CRYGC
    • Crystallin gamma 3
    • Crystallin gamma C
    • Gamma C crystallin
    • Gamma crystallin 2 1
    • Gamma crystallin 3
    • Gamma crystallin C
    • Gamma-C-crystallin
    • Gamma-crystallin 2-1
    • Gamma-crystallin 3
    • Gamma-crystallin C
    • Gammab cry
    • Len
    see all
  • Function

    Crystallins are the dominant structural components of the vertebrate eye lens.
  • Involvement in disease

    Defects in CRYGC are a cause of cataract autosomal dominant (ADC) [MIM:604219]. Cataract is an opacification of the crystalline lens of the eye that frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. In general, the more posteriorly located and dense an opacity, the greater the impact on visual function. Cataract is the most common treatable cause of visual disability in childhood.
    Defects in CRYGC are a cause of cataract Coppock-like (CCL) [MIM:604307]. A congenital pulverulent disk-like opacity involving the embryonic nucleus with many tiny white dots in the lamellar portion of the lens. It is usually bilateral and dominantly inherited.
  • Sequence similarities

    Belongs to the beta/gamma-crystallin family.
    Contains 4 beta/gamma crystallin 'Greek key' domains.
  • Domain

    Has a two-domain beta-structure, folded into four very similar Greek key motifs.
  • Information by UniProt

Images

  • 15% SDS-PAGE showing ab126922 (3 µg).

References

ab126922 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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