Recombinant Human GAS2 protein (ab158499)

Our Abpromise guarantee covers the use of ab158499 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Alternative names
- GAS 2
- GAS-2
- Gas2
- GAS2_HUMAN
- Growth arrest specific 2
- Growth arrest specific protein 2
- Growth arrest-specific protein 2
- MGC32610
see all
Function

May play a role in apoptosis by acting as a cell death substrate for caspases. Is cleaved during apoptosis and the cleaved form induces dramatic rearrangements of the actin cytoskeleton and potent changes in the shape of the affected cells. May be involved in the membrane ruffling process.
Tissue specificity

Ubiquitously expressed with highest levels in liver, lung, and kidney. Not found in spleen.
Sequence similarities

Belongs to the GAS2 family.
Contains 1 CH (calponin-homology) domain.
Contains 1 GAR domain.
Developmental stage

Specifically expressed at growth arrest.
Post-translational
modifications

Cleaved, during apoptosis, on a specific aspartic residue by caspases.
Phosphorylated on serine residues during the G0-G1 transition phase.
Cellular localization

Cytoplasm > cytoskeleton. Membrane. Component of the microfilament system. Colocalizes with actin fibers at the cell border and along the stress fibers in growth-arrested fibroblasts. Mainly membrane-associated. When hyperphosphorylated, accumulates at membrane ruffles.
Target information above from: UniProt accession O43903 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt

SDS-PAGE - Recombinant Human GAS2 protein (ab158499)

ab158499 on a 12.5% SDS-PAGE stained with Coomassie Blue.

ab158499 has not yet been referenced specifically in any publications.

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