Recombinant Human GAS2 protein (ab158499)
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- References
- Protocols
Overview
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Product nameRecombinant Human GAS2 protein
See all GAS2 proteins and peptides -
Protein lengthFull length protein
Description
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NatureRecombinant
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SourceWheat germ
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Amino Acid Sequence
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SpeciesHuman
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SequenceMCTALSPKVRSGPGLSDMHQYSQWLASRHEANLLPMKEDLALWLTNLLGK EITAETFMEKLDNGALLCQLAETMQEKFKESMDANKPTKNLPLKKIPCKT SAPSGSFFARDNTANFLSWCRDLGVDETCLFESEGLVLHKQPREVCLCLL ELGRIAARYGVEPPGLIKLEKEIEQEETLSAPSPSPSPSSKSSGKKSTGN LLDDAVKRISEDPPCKCPNKFCVERLSQGRYRVGEKILFIRMLHNKHVMV RVGGGWETFAGYLLKHDPCRMLQISRVDGKTSPIQSKSPTLKDMNPDNYL VVSASYKAKKEIK
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Amino acids1 to 313
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Tagsproprietary tag N-Terminus
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Specifications
Our Abpromise guarantee covers the use of ab158499 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Applications
ELISA
Western blot
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FormLiquid
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Additional notesProtein concentration is above or equal to 0.05 mg/ml.
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Concentration information loading...
Preparation and Storage
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Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00
Constituents: 0.31% Glutathione, 0.79% Tris HCl
General Info
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Alternative names
- GAS 2
- GAS-2
- Gas2
see all -
FunctionMay play a role in apoptosis by acting as a cell death substrate for caspases. Is cleaved during apoptosis and the cleaved form induces dramatic rearrangements of the actin cytoskeleton and potent changes in the shape of the affected cells. May be involved in the membrane ruffling process.
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Tissue specificityUbiquitously expressed with highest levels in liver, lung, and kidney. Not found in spleen.
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Sequence similaritiesBelongs to the GAS2 family.
Contains 1 CH (calponin-homology) domain.
Contains 1 GAR domain. -
Developmental stageSpecifically expressed at growth arrest.
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Post-translational
modificationsCleaved, during apoptosis, on a specific aspartic residue by caspases.
Phosphorylated on serine residues during the G0-G1 transition phase. -
Cellular localizationCytoplasm > cytoskeleton. Membrane. Component of the microfilament system. Colocalizes with actin fibers at the cell border and along the stress fibers in growth-arrested fibroblasts. Mainly membrane-associated. When hyperphosphorylated, accumulates at membrane ruffles.
- Information by UniProt
Images
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SDS-PAGE - Recombinant Human GAS2 protein (ab158499)ab158499 on a 12.5% SDS-PAGE stained with Coomassie Blue.
Datasheets and documents
References
ab158499 has not yet been referenced specifically in any publications.
