Bioactive grade

Recombinant human GDF15 protein (ab125769)

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Description

  • Product name

    Recombinant human GDF15 protein
    See all GDF15 proteins and peptides

  • Biological activity

    ab125769 is a non-glycosylated, disulfide linked homodimer. It is comprised of two identical 120 amino acid monomers. The activity is determined by the inhibition of DU-145 cells and is typically 1-2 (μg/mL).

  • Purity

    > 95 % SDS-PAGE.

  • Endotoxin level

    < 0.100 Eu/µg

  • Expression system

    Escherichia coli

  • Accession

    Q99988

  • Protein length

    Full length protein

  • Animal free

    No

  • Nature

    Recombinant

    • Species

      Human

    • Sequence

      MARNGDHCPL GPGRCCRLHT VRASLEDLGW ADWVLSPREV QVTMCIGACP SQFRAANMHA QIKTSLHRLK PDTVPAPCCV PASYNPMVLI QKTDTGVSLQ TYDDLLAKDC HCI

    • Amino acids

      197 to 308

    • Additional sequence information

      This product refers to the processed mature form of this protein from aa 195 to 308. The signal peptide and propeptide are removed.

Specifications

Our Abpromise guarantee covers the use of ab125769 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Functional Studies

    SDS-PAGE

  • Form

    Lyophilised

  • Additional notes

    Lyophilized product is very stable at -20°C. Reconstituted material should be aliquoted and frozen at -20°C. It is recommended that a carrier protein (0.1% HSA or BSA) is added for long term storage.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Please see notes section.

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

  • Reconstitution
    Centrifuge vial before opening. It is recommended to reconstitute the lyophilized product with sterile 5 mM acetic acid at a concentration of 0.1 mg/ml, which can be further diluted into other aqueous solutions.

General Info

  • Alternative names

    • GDF 15
    • GDF-15
    • Gdf15
    • GDF15_HUMAN
    • Growth differentiation factor 15
    • Growth/differentiation factor 15
    • Macrophage inhibitory cytokine 1
    • MIC 1
    • Mic-1
    • MIC1
    • NAG 1
    • NAG-1
    • NAG1
    • NRG 1
    • NRG-1
    • NRG1
    • NSAID
    • NSAID (nonsteroidal anti inflammatory drug) activated protein 1
    • NSAID regulated protein 1
    • NSAID-activated gene 1 protein
    • NSAID-regulated gene 1 protein
    • PDF
    • PLAB
    • Placental bone morphogenetic protein
    • Placental bone morphogenic protein
    • Placental TGF beta
    • Placental TGF-beta
    • Prostate differentiation factor
    • PTGF beta
    • PTGFB
    see all

  • Tissue specificity

    Highly expressed in placenta, with lower levels in prostate and colon and some expression in kidney.

  • Sequence similarities

    Belongs to the TGF-beta family.

  • Cellular localization

    Secreted.
  • Information by UniProt

References

This product has been referenced in:

See 1 Publication for this product

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