The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
< 1.000 Eu/µg
>95% by SDS-PAGE . Purity is greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. The lyophilized protein is stable for a few weeks at room temperature. Store at -80°C. Avoid freeze / thaw cycle.
pH: 7.40 Constituent: 100% PBS
Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100 µg/ml.
Dissolve the lyophilized protein in 3X PBS.
After reconstitution aliquot and store at < -20°C, avoid freeze/thaw cycles.
Astrocyte derived trophic factor
Astrocyte derived trophic factor 1
Astrocyte-derived trophic factor
Glial cell derived neurotrophic factor
Glial Cell Line Derived Neurotrophic Factor
Glial cell line-derived neurotrophic factor
Glial derived neurotrophic factor
Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake.
In the brain, predominantly expressed in the striatum with highest levels in the caudate and lowest in the putamen.
Involvement in disease
Defects in GDNF may be a cause of Hirschsprung disease (HSCR) [MIM:142623]. In association with mutations of RET gene, defects in GDNF may be involved in Hirschsprung disease. This genetic disorder of neural crest development is characterized by the absence of intramural ganglion cells in the hindgut, often resulting in intestinal obstruction. Defects in GDNF are a cause of congenital central hypoventilation syndrome (CCHS) [MIM:209880]; also known as congenital failure of autonomic control or Ondine curse. CCHS is a rare disorder characterized by abnormal control of respiration in the absence of neuromuscular or lung disease, or an identifiable brain stem lesion. A deficiency in autonomic control of respiration results in inadequate or negligible ventilatory and arousal responses to hypercapnia and hypoxemia.