Recombinant Human GLE1 protein (ab158531)
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- References
- Protocols
Overview
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Product nameRecombinant Human GLE1 protein
See all GLE1 proteins and peptides -
Protein lengthFull length protein
Description
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NatureRecombinant
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SourceWheat germ
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Amino Acid Sequence
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SpeciesHuman
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SequenceMPSEGRCWETLKALRSSDKGRLCYYRDWLLRREDVLEECMSLPKLSSYSG WVVEHVLPHMQENQPLSETSPSSTSASALDQPSFVPKSPDASSAFSPASP ATPNGTKGKDESQHTESMVLQSSRGIKVEDCVRMYELVHRMKGTEGLRLW QEEQERKVQALSEMASEQLKRFDEWKELKQHKEFQDLREVMEKSSREALG HQEKLKAEHRHRAKILNLKLREAEQQRVKQAEQERLRKEEGQIRLRALYA LQEEMLQLSQQLDASEQHKALLKVDLAAFQTRGNQLCSLISGIIRASSES SYPTAESQAEAERALREMRDLLMNLGQEITRACEDKRRQDEEEAQVKLQE AQMQQGPEAHKEPPAPSQGPGGKQNEDLQVKVQDITMQWYQQLQDASMQC VLTFEGLTNSKDSQAKKIKMDLQKAATIPVSQISTIAGSKLKEIFDKIHS LLSGKPVQSGGRSVSVTLNPQGLDFVQYKLAEKFVKQGEEEVASHHEAAF PIAVVASGIWELHPRVGDLILAHLHKKCPYSVPFYPTFKEGMALEDYQRM LGYQVKDSKVEQQDNFLKRMSGMIRLYAAIIQLRWPYGNQQEIHPHGLNH GWRWLAQILNMEPLSDVTATLLFDFLEVCGNALMKQYQVQFWKMLILIKE DYFPRIEAITSSGQMGSFIRLKQFLEKCLQHKDIPVPKGFLTSSFWRS
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Amino acids1 to 698
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TagsGST tag N-Terminus
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Specifications
Our Abpromise guarantee covers the use of ab158531 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Applications
Western blot
ELISA
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FormLiquid
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Additional notesProtein concentration is above or equal to 0.05 mg/ml.
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Concentration information loading...
Preparation and Storage
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Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00
Constituents: 0.31% Glutathione, 0.79% Tris HCl
General Info
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Alternative names
- GLE 1
- GLE1
- GLE1 like protein
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FunctionRequired for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC).
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Involvement in diseaseDefects in GLE1 are the cause of lethal congenital contracture syndrome type 1 (LCCS1) [MIM:253310]; also known as multiple contracture syndrome type Finnish. LCCS is an autosomal recessive disorder characterized by early fetal hydrops and akinesia, micrognatia, pulmonary hypoplasia, pterygia, multiple joint contractures, specific neuropathology with degeneration of anterior horn neurons and extreme skeletal muscle atrophy. LCCS1 leads to prenatal death.
Defects in GLE1 are the cause of lethal arthrogryposis with anterior horn cell disease (LAAHD) [MIM:611890]. LAAHD is characterized by fetal akinesia, arthrogryposis and motor neuron loss. LAADH fetus often survive delivery, but die early as a result of respiratory failure. Neuropathological findings resemble those of LCCS1, but are less severe. -
Sequence similaritiesBelongs to the GLE1 family.
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Cellular localizationNucleus. Cytoplasm. Shuttles between the nucleus and the cytoplasm. Shuttling is essential for its mRNA export function and Cytoplasm. Nucleus > nuclear pore complex. Shuttles between the nucleus and the cytoplasm. In the nucleus, isoform 1 localizes to the nuclear pore complex and nuclear envelope. Shuttling is essential for its mRNA export function.
- Information by UniProt
Images
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SDS-PAGE - Recombinant Human GLE1 protein (ab158531)ab158531 on a 12.5% SDS-PAGE stained with Coomassie Blue.
Datasheets and documents
References
ab158531 has not yet been referenced specifically in any publications.
