The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Protein concentration is above or equal to 0.05 mg/ml.
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Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.31% Glutathione, 0.79% Tris HCl
3 hydroxyisobutyrate dehydrogenase like protein
3-hydroxyisobutyrate dehydrogenase-like protein
Cytokine like nuclear factor n pac
Cytokine-like nuclear factor N-PAC
Glyoxylate reductase 1 homolog
Nuclear protein 60 kDa
Nuclear protein NP60
Nuclear protein of 60 kDa
Putative oxidoreductase GLYR1
May have oxidoreductase activity. Regulates p38 MAP kinase activity by mediating stress activation of p38alpha/MAPK14 and specifically regulating MAPK14 signaling. Indirectly promotes phosphorylation of MAPK14 and activation of ATF2. The phosphorylation of MAPK14 requires upstream activity of MAP2K4 and MAP2K6. Recruited on chromatin, recognizes and binds trimethylated 'Lys-36' of histone H3 (H3K36me3).
Belongs to the 3-hydroxyisobutyrate dehydrogenase family. NP60 subfamily. Contains 1 A.T hook DNA-binding domain. Contains 1 PWWP domain.
The A.T hook DNA-binding domain is required for the interaction with MAPK14. The PWWP domain probably mediates the binding to H3K36me3.