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    recombinant-human-gnrh-protein-ab112295.pdf

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Recombinant Human GnRH protein (ab112295)

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SDS-PAGE - Recombinant Human GnRH protein (ab112295)

    Key features and details

    • Expression system: Wheat germ
    • Tags: GST tag N-Terminus
    • Suitable for: ELISA, SDS-PAGE, WB

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    Description

    • Product name

      Recombinant Human GnRH protein
      See all GnRH proteins and peptides
    • Biological activity

      useful for Antibody Production and Protein Array
    • Expression system

      Wheat germ
    • Accession

      P01148
    • Protein length

      Full length protein
    • Animal free

      No
    • Nature

      Recombinant
      • Species

        Human
      • Sequence

        MKPIQKLLAGLILLTWCVEGCSSQHWSYGLRPGGKRDAENLIDSFQEIVK EVGQLAETQRFECTTHQPRSPLRDLKGALESLIEEETGQKKI
      • Predicted molecular weight

        36 kDa including tags
      • Amino acids

        1 to 92
      • Tags

        GST tag N-Terminus

    Specifications

    Our Abpromise guarantee covers the use of ab112295 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • Applications

      ELISA

      SDS-PAGE

      Western blot

    • Form

      Liquid
    • Additional notes

      useful for Antibody Production and Protein Array
    • Concentration information loading...

    Preparation and Storage

    • Stability and Storage

      Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

      pH: 8.00
      Constituents: 0.31% Glutathione, 0.79% Tris HCl

      Glutathione is reduced

    General Info

    • Alternative names

      • GnRH associated peptide 1
      • GNRH1
      • Gonadotrophin releasing hormone 1
      • GRH
      • HH12
      • LHRH
      • LNRH
      • Luliberin I
      • Luteinizing releasing hormone
      • Lutenizing hormome releasing hormone
      • Progonadoliberin 1
      • Progonadoliberin I
      • Prolactin release inhibiting factor
      see all
    • Relevance

      Gonadotropin releasing hormone (GnRH), also known as luteinizing hormone releasing hormone (LHRH), is a key molecule in the regulation of reproduction in vertebrates. GnRH, a decapeptide, is produced by neurons in the medial basal hypothalamus (MBH) and secreted in a pulsatile manner into the cardiovascular system. The frequency and amplitude of GnRH pulses determine secretion of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary. Higher frequencies (greater than one pulse per hour) stimulate LH secretion while lower frequencies stimulate FSH secretion. The generation of GnRH pulses is effected by numerous stimuli, such as neural, hormonal and environmental. Therefore, behavioral and physiological conditions such as sleep, exercise, and stress can affect the GnRH pulses and cause a disruption of the normal cycle. Recent studies show that GnRH also has a role in mediating cancer. GnRH has been shown to inhibit the growth of human uterine leiomyloma cells by suppressing proliferation and inducing apoptosis. GnRH analogs have been used to treat a wide variety of reproductive cancers, although the side effects of using such compounds are often quite severe.
    • Cellular localization

      Secreted

    Images

    • SDS-PAGE - Recombinant Human GnRH protein (ab112295)
      SDS-PAGE - Recombinant Human GnRH protein (ab112295)
      ab112295 analysed on a 12.5% SDS-PAGE stained with Coomassie Blue.

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    Datasheets and documents

    • Datasheet download

      Download

    References (0)

    Publishing research using ab112295? Please let us know so that we can cite the reference in this datasheet.

    ab112295 has not yet been referenced specifically in any publications.

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