Overview

Description

  • Nature

    Recombinant
  • Source

    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species

      Human
    • Molecular weight

      21 kDa
    • Amino acids

      377 to 550
    • Tags

      His-DHFR tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab127378 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Purity

    > 95 % Purified via His tag.
    >95% by SDS-PAGE.
  • Form

    Lyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20ºC.

    Constituents: 0.32% Tris HCl, 0.58% Sodium chloride

  • Reconstitution
    Reconstitute with water to desired concentration

General Info

  • Alternative names

    • arhgap26
    • FLJ42530
    • GRAF
    • GRAF1
    • GTPase regulator associated with focal adhesion kinase
    • GTPase regulator associated with focal adhesion kinase pp125(FAK)
    • KIAA0621
    • oligophrenin 1 like protein
    • Oligophrenin-1-like protein
    • oligophrenin1like protein
    • OPHN1L
    • OPHN1L1
    • RHG26_HUMAN
    • Rho GTPase activating protein 26
    • Rho GTPase activating protein26
    • Rho GTPase-activating protein 26
    • Rho-type GTPase-activating protein 26
    see all
  • Function

    GTPase-activating protein for RHOA and CDC42.
  • Involvement in disease

    Defects in ARHGAP26 are a cause of juvenile myelomonocytic leukemia (JMML) [MIM:607785]. JMML is a pediatric myelodysplastic syndrome that constitutes approximately 30% of childhood cases of myelodysplastic syndrome (MDS) and 2% of leukemia. Chromosomal translocation t(5;11)(q31;q23) with MLL has been found in a JMML patient.
  • Sequence similarities

    Contains 1 PH domain.
    Contains 1 Rho-GAP domain.
    Contains 1 SH3 domain.
  • Cellular localization

    Cell junction > focal adhesion. Cytoplasm > cytoskeleton. Colocalizes with actin stress fibers and cortical actin structures.
  • Information by UniProt

References

ab127378 has not yet been referenced specifically in any publications.

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