Grancalcin is a calcium binding protein abundant in neutrophils and macrophages. It belongs to the penta EF hand subfamily of proteins which includes sorcin, calpain, and ALG2. Grancalcin localization is dependent upon calcium and magnesium. In the absence of divalent cation, grancalcin localizes to the cytosolic fraction; with magnesium alone, it partitions with the granule fraction; and in the presence of magnesium and calcium, it associates with both the granule and membrane fractions, suggesting a role for grancalcin in granule membrane fusion and degranulation.
50% cytoplasmic, the remainder being attached to the membranes and granules.
SDS-PAGE - Recombinant Human Grancalcin protein (ab103054)
15% SDS-PAGE analysis of 3µg ab103054.
has not yet been referenced specifically in any publications.
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