The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Specific Activity: ~110U/µg protein. One unit is defined as the amount of enzyme that hydrolyzes 1nmol Z-Lys-SBzl per min. at 25°C in 0.05M TRIS, pH 8.0, containing 0.15M NaCl, 0.01% Triton X-100 and 0.3mM DTNB.
Do not dilute to more than 0.2mg/ml. Do not store dilute solutions (1-1000ng/ml) for more than 24 hours.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
This product is an active protein and may elicit a biological response in vivo, handle with caution.
Cytolytic t cell and natural killer cell specific trypsin like serine protease
Cytotoxic T lymphocyte associated serine esterase 3
Cytotoxic T lymphocyte proteinase 1
Cytotoxic T-lymphocyte proteinase 1
Granzyme 1 cytotoxic T lymphocyte associated serine esterase 3
Granzyme A (Cytotoxic T lymphocyte associated serine esterase 3; Hanukah factor serine protease)
Granzyme A (granzyme 1, cytotoxic T lymphocyte associated serine esterase 3)
Granzyme A precursor
Hanukah factor serine protease
This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Lys or Arg. Cleaves APEX1 after 'Lys-31' and destroys its oxidative repair activity. Involved in apoptosis.
Belongs to the peptidase S1 family. Granzyme subfamily. Contains 1 peptidase S1 domain.