Recombinant Human Granzyme M protein (ab158624)

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Description

  • Product name

    Recombinant Human Granzyme M protein

  • Expression system

    Wheat germ

  • Protein length

    Full length protein

  • Animal free

    No

  • Nature

    Recombinant

    • Species

      Human

    • Sequence

      MEACVSSLLVLALGALSVGSSFGTQIIGGREVIPHSRPYMASLQRNGSHL CGGVLVHPKWVLTAAHCLAQRMAQLRLVLGLHTLDSPGLTFHIKAAIQHP RYKPVPALENDLALLQLDGKVKPSRTIRPLALPSKRQVVAAGTRCSMAGW GLTHQGGRLSRVLRELDLQVLDTRMCNNSRFWNGSLSPSMVCLAADSKDQ APCKGDSGGPLVCGKGRVLAGVLSFSSRVCTDIFKPPVATAVAPYVSWIR KVTGRSA

    • Amino acids

      1 to 257

    • Tags

      GST tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab158624 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    ELISA

  • Form

    Liquid

  • Additional notes

     

     

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names

    • GRAM_HUMAN
    • Granzyme M
    • Granzyme M (lymphocyte met ase 1)
    • GranzymeM
    • GZM M
    • Gzmm
    • HU Met 1
    • HU-Met-1
    • LMET 1
    • LMET1
    • Lymphocyte met ase 1
    • MET 1
    • Met 1 serine protease
    • Met ase
    • Met-1 serine protease
    • Met-ase
    • MET1
    • Met1 serine protease
    • Natural killer cell granular protease
    see all

  • Function

    Cleaves peptide substrates after methionine, leucine, and norleucine. Physiological substrates include EZR, alpha-tubulins and the apoptosis inhibitor BIRC5/Survivin. Promotes caspase activation and subsequent apoptosis of target cells.

  • Tissue specificity

    Highly and constitutively expressed in activated natural killer (NK) cells.

  • Sequence similarities

    Belongs to the peptidase S1 family. Granzyme subfamily.
    Contains 1 peptidase S1 domain.

  • Cellular localization

    Secreted. Cytoplasmic granule. Granules of large granular lymphocytes.
  • Information by UniProt

Images

  • SDS-PAGE - Recombinant Human Granzyme M protein (ab158624)
    SDS-PAGE - Recombinant Human Granzyme M protein (ab158624)
    ab158624 on a 12.5% SDS-PAGE stained with Coomassie Blue.

References

ab158624 has not yet been referenced specifically in any publications.

Publishing research using ab158624? Please let us know so that we can cite the reference in this datasheet.

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