Recombinant Human Granzyme M protein (ab158624)

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SDS-PAGE - Recombinant Human Granzyme M protein (ab158624)

    Key features and details

    • Expression system: Wheat germ
    • Tags: GST tag N-Terminus
    • Suitable for: WB, ELISA

    Description

    • Product name

      Recombinant Human Granzyme M protein

    • Expression system

      Wheat germ

    • Protein length

      Full length protein

    • Animal free

      No

    • Nature

      Recombinant

      • Species

        Human

      • Sequence

        MEACVSSLLVLALGALSVGSSFGTQIIGGREVIPHSRPYMASLQRNGSHL CGGVLVHPKWVLTAAHCLAQRMAQLRLVLGLHTLDSPGLTFHIKAAIQHP RYKPVPALENDLALLQLDGKVKPSRTIRPLALPSKRQVVAAGTRCSMAGW GLTHQGGRLSRVLRELDLQVLDTRMCNNSRFWNGSLSPSMVCLAADSKDQ APCKGDSGGPLVCGKGRVLAGVLSFSSRVCTDIFKPPVATAVAPYVSWIR KVTGRSA

      • Amino acids

        1 to 257

      • Tags

        GST tag N-Terminus

    Specifications

    Our Abpromise guarantee covers the use of ab158624 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • Applications

      Western blot

      ELISA

    • Form

      Liquid

    • Additional notes

       

       

    • Concentration information loading...

    Preparation and Storage

    • Stability and Storage

      Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

      pH: 8.00
      Constituents: 0.31% Glutathione, 0.79% Tris HCl

    General Info

    • Alternative names

      • GRAM_HUMAN
      • Granzyme M
      • Granzyme M (lymphocyte met ase 1)
      • GranzymeM
      • GZM M
      • Gzmm
      • HU Met 1
      • HU-Met-1
      • LMET 1
      • LMET1
      • Lymphocyte met ase 1
      • MET 1
      • Met 1 serine protease
      • Met ase
      • Met-1 serine protease
      • Met-ase
      • MET1
      • Met1 serine protease
      • Natural killer cell granular protease
      see all

    • Function

      Cleaves peptide substrates after methionine, leucine, and norleucine. Physiological substrates include EZR, alpha-tubulins and the apoptosis inhibitor BIRC5/Survivin. Promotes caspase activation and subsequent apoptosis of target cells.

    • Tissue specificity

      Highly and constitutively expressed in activated natural killer (NK) cells.

    • Sequence similarities

      Belongs to the peptidase S1 family. Granzyme subfamily.
      Contains 1 peptidase S1 domain.

    • Cellular localization

      Secreted. Cytoplasmic granule. Granules of large granular lymphocytes.
    • Information by UniProt

    Images

    • SDS-PAGE - Recombinant Human Granzyme M protein (ab158624)
      SDS-PAGE - Recombinant Human Granzyme M protein (ab158624)
      ab158624 on a 12.5% SDS-PAGE stained with Coomassie Blue.

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    References (0)

    Publishing research using ab158624? Please let us know so that we can cite the reference in this datasheet.

    ab158624 has not yet been referenced specifically in any publications.

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