Recombinant Human Granzyme M protein (ab158624)

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Overview

Description

  • Nature
    Recombinant
  • Source
    Wheat germ
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      MEACVSSLLVLALGALSVGSSFGTQIIGGREVIPHSRPYMASLQRNGSHL CGGVLVHPKWVLTAAHCLAQRMAQLRLVLGLHTLDSPGLTFHIKAAIQHP RYKPVPALENDLALLQLDGKVKPSRTIRPLALPSKRQVVAAGTRCSMAGW GLTHQGGRLSRVLRELDLQVLDTRMCNNSRFWNGSLSPSMVCLAADSKDQ APCKGDSGGPLVCGKGRVLAGVLSFSSRVCTDIFKPPVATAVAPYVSWIR KVTGRSA
    • Amino acids
      1 to 257
    • Tags
      proprietary tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab158624 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    ELISA

  • Form
    Liquid
  • Additional notes
    Protein concentration is above or equal to 0.05 mg/ml.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names
    • GRAM_HUMAN
    • Granzyme M
    • Granzyme M (lymphocyte met ase 1)
    • GranzymeM
    • GZM M
    • Gzmm
    • HU Met 1
    • HU-Met-1
    • LMET 1
    • LMET1
    • Lymphocyte met ase 1
    • MET 1
    • Met 1 serine protease
    • Met ase
    • Met-1 serine protease
    • Met-ase
    • MET1
    • Met1 serine protease
    • Natural killer cell granular protease
    see all
  • Function
    Cleaves peptide substrates after methionine, leucine, and norleucine. Physiological substrates include EZR, alpha-tubulins and the apoptosis inhibitor BIRC5/Survivin. Promotes caspase activation and subsequent apoptosis of target cells.
  • Tissue specificity
    Highly and constitutively expressed in activated natural killer (NK) cells.
  • Sequence similarities
    Belongs to the peptidase S1 family. Granzyme subfamily.
    Contains 1 peptidase S1 domain.
  • Cellular localization
    Secreted. Cytoplasmic granule. Granules of large granular lymphocytes.
  • Information by UniProt

Images

  • SDS-PAGE - Human Granzyme M full length protein (ab158624)
    SDS-PAGE - Human Granzyme M full length protein (ab158624)
    ab158624 on a 12.5% SDS-PAGE stained with Coomassie Blue.

References

ab158624 has not yet been referenced specifically in any publications.

Publishing research using ab158624? Please let us know so that we can cite the reference in this datasheet.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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