The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Protein concentration is above or equal to 0.05 mg/ml.
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Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.31% Glutathione, 0.79% Tris HCl
Granzyme M (lymphocyte met ase 1)
HU Met 1
Lymphocyte met ase 1
Met 1 serine protease
Met-1 serine protease
Met1 serine protease
Natural killer cell granular protease
Cleaves peptide substrates after methionine, leucine, and norleucine. Physiological substrates include EZR, alpha-tubulins and the apoptosis inhibitor BIRC5/Survivin. Promotes caspase activation and subsequent apoptosis of target cells.
Highly and constitutively expressed in activated natural killer (NK) cells.
Belongs to the peptidase S1 family. Granzyme subfamily. Contains 1 peptidase S1 domain.
Secreted. Cytoplasmic granule. Granules of large granular lymphocytes.