Name: Recombinant Human GRB2 protein
SKU: ab116430

Our Abpromise guarantee covers the use of ab116430 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Alternative names
- Abundant SRC homology
- Adapter protein GRB2
- ASH
- Ash protein
- EGFRBP GRB2
- Epidermal growth factor receptor binding protein
- Epidermal growth factor receptor binding protein GRB2
- GRB 2
- Grb2
- GRB2 adapter protein
- GRB2_HUMAN
- Grb3 3
- Growth factor receptor bound protein 2
- Growth factor receptor bound protein 3
- Growth factor receptor-bound protein 2
- HT027
- MST084
- MSTP084
- NCKAP2
- OTTHUMP00000166096
- OTTHUMP00000166097
- OTTHUMP00000166098
- Protein ash
- SEM5
- SH2/SH3 adapter GRB2
see all
Function

Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway.
Isoform GRB3-3 does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Isoform GRB3-3 acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death.
Sequence similarities

Belongs to the GRB2/sem-5/DRK family.
Contains 1 SH2 domain.
Contains 2 SH3 domains.
Domain

The SH3 domains mediate interaction with RALGPS1 and SHB.
Cellular localization

Golgi apparatus.
Target information above from: UniProt accession P62993 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt

Western blot - Recombinant Human GRB2 protein (ab116430)

10% SDS-PAGE stained with Coomassie Blue (Lane 1), immunobloting with anti-6xHis (Lane 2)

ab116430 has not yet been referenced specifically in any publications.

Publishing research using ab116430? Please let us know so that we can cite the reference in this datasheet.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

Recombinant Human GRB2 protein (ab116430)