Product nameRecombinant Human GRB2 protein
See all GRB2 proteins and peptides
Protein lengthFull length protein
Amino Acid Sequence
SequenceMEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPK NYIEMKPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVK FGNDVQHFKVLRDGAGKYFLWVVKFNSLNELVDYHRSTSVSRNQQIFLRD IEQVPQQPTYVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHG QTGMFPRNYVTPVNRNVLEHHHHHH
Molecular weight26 kDa including tags
Amino acids1 to 217
TagsHis tag C-Terminus
- Anti-GRB2 antibody (ab109651)
- Anti-GRB2 antibody (ab111031)
- Anti-GRB2 antibody (ab14299)
- Anti-6X His tag® antibody [HIS.H8] (ab18184)
- Anti-GRB2 antibody (ab2234)
- Anti-GRB2 antibody [Y237] (ab32037)
- Anti-GRB2 antibody [Y301] (ab32111)
- Anti-6X His tag® antibody [4D11] (ab5000)
- Anti-GRB2 antibody (ab79876)
- Anti-GRB2 antibody - N-terminal (ab80065)
- Anti-6X His tag® antibody - ChIP Grade (ab9108)
Our Abpromise guarantee covers the use of ab172149 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Endotoxin level< 1.000 Eu/µg
Purity>95% by SDS-PAGE .
Concentration information loading...
Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
Constituents: 0.88% Sodium chloride, 0.32% Tris HCl
ReconstitutionAlways centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 µg/ml. Dissolve the lyophilized protein in 1X PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
- Abundant SRC homology
- Adapter protein GRB2
FunctionAdapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway.
Isoform GRB3-3 does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Isoform GRB3-3 acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death.
Sequence similaritiesBelongs to the GRB2/sem-5/DRK family.
Contains 1 SH2 domain.
Contains 2 SH3 domains.
DomainThe SH3 domains mediate interaction with RALGPS1 and SHB.
Cellular localizationGolgi apparatus.
- Information by UniProt
ab172149 has not yet been referenced specifically in any publications.