Recombinant Human GRP78 BiP protein (ab167897)

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Description

  • Product name

    Recombinant Human GRP78 BiP protein
    See all GRP78 BiP proteins and peptides

  • Purity

    > 90 % SDS-PAGE.
    ab167897 is purified by using conventional chromatography techniques.

  • Expression system

    Escherichia coli

  • Accession

    P11021

  • Protein length

    Full length protein

  • Animal free

    No

  • Nature

    Recombinant

    • Species

      Human

    • Sequence

      MGSSHHHHHH SSGLVPRGSH MGSEEEDKKE DVGTVVGIDL GTTYSCVGVF KNGRVEIIAN DQGNRITPSY VAFTPEGERL IGDAAKNQLT SNPENTVFDA KRLIGRTWND PSVQQDIKFL PFKVVEKKTK PYIQVDIGGG QTKTFAPEEI SAMVLTKMKE TAEAYLGKKV THAVVTVPAY FNDAQRQATK DAGTIAGLNV MRIINEPTAA AIAYGLDKRE GEKNILVFDL GGGTFDVSLL TIDNGVFEVV ATNGDTHLGG EDFDQRVMEH FIKLYKKKTG KDVRKDNRAV QKLRREVEKA KRALSSQHQA RIEIESFYEG EDFSETLTRA KFEELNMDLF RSTMKPVQKV LEDSDLKKSD IDEIVLVGGS TRIPKIQQLV KEFFNGKEPS RGINPDEAVA YGAAVQAGVL SGDQDTGDLV LLDVCPLTLG IETVGGVMTK LIPRNTVVPT KKSQIFSTAS DNQPTVTIKV YEGERPLTKD NHLLGTFDLT GIPPAPRGVP QIEVTFEIDV NGILRVTAED KGTGNKNKIT ITNDQNRLTP EEIERMVNDA EKFAEEDKKL KERIDTRNEL ESYAYSLKNQ IGDKEKLGGK LSSEDKETME KAVEEKIEWL ESHQDADIED FKAKKKELEE IVQPIISKLY GSAGPPPTGE EDTAEKDEL

    • Predicted molecular weight

      73 kDa including tags

    • Amino acids

      19 to 654

    • Tags

      His tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab167897 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 0.02% DTT, 0.32% Tris HCl, 20% Glycerol, 0.88% Sodium chloride

General Info

  • Alternative names

    • 78 kDa glucose regulated protein
    • 78 kDa glucose-regulated protein
    • AL022860
    • AU019543
    • BIP
    • D2Wsu141e
    • D2Wsu17e
    • Endoplasmic reticulum lumenal Ca(2+)-binding protein grp78
    • Endoplasmic reticulum lumenal Ca2+ binding protein grp78
    • Epididymis secretory sperm binding protein Li 89n
    • FLJ26106
    • Glucose Regulated Protein 78
    • Glucose Regulated Protein 78kDa
    • GRP 78
    • GRP-78
    • GRP78
    • GRP78_HUMAN
    • Heat shock 70 kDa protein 5
    • Heat Shock 70kDa Protein 5
    • Heat shock protein family A (Hsp70) member 5
    • HEL S 89n
    • Hsce70
    • HSPA 5
    • HSPA5
    • Immunoglobulin Heavy Chain Binding Protein
    • Immunoglobulin heavy chain-binding protein
    • mBiP
    • MIF2
    • Sez7
    see all

  • Function

    Probably plays a role in facilitating the assembly of multimeric protein complexes inside the endoplasmic reticulum. Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10, probably to facilitate the release of DNAJC10 from its substrate.

  • Involvement in disease

    Autoantigen in rheumatoid arthritis.

  • Sequence similarities

    Belongs to the heat shock protein 70 family.

  • Cellular localization

    Endoplasmic reticulum lumen. Melanosome. Cytoplasm. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
  • Information by UniProt

Images

  • SDS-PAGE - Recombinant Human GRP78 BiP protein (ab167897)
    SDS-PAGE - Recombinant Human GRP78 BiP protein (ab167897)
    15% SDS-PAGE of ab167897 (3µg)

References

ab167897 has not yet been referenced specifically in any publications.

Publishing research using ab167897? Please let us know so that we can cite the reference in this datasheet.

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