Product nameRecombinant human GRP78 BiP protein (His tag)
See all GRP78 BiP proteins and peptides
Protein lengthFull length protein
Amino Acid Sequence
Molecular weight78 kDa
Additional sequence informationhis-tagged
Our Abpromise guarantee covers the use of ab78432 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
competitive binding assays
Purity> 90 % SDS-PAGE.
Ab78432 is purified by affinity purification.
Concentration information loading...
Preparation and Storage
Stability and Storage
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
Constituents: 0.37% Potassium chloride, 0.05% Magnesium chloride, 0.015% DTT, 0.24% Tris
This product is an active protein and may elicit a biological response in vivo, handle with caution.
- 78 kDa glucose regulated protein
- 78 kDa glucose-regulated protein
FunctionProbably plays a role in facilitating the assembly of multimeric protein complexes inside the endoplasmic reticulum. Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10, probably to facilitate the release of DNAJC10 from its substrate.
Involvement in diseaseAutoantigen in rheumatoid arthritis.
Sequence similaritiesBelongs to the heat shock protein 70 family.
Cellular localizationEndoplasmic reticulum lumen. Melanosome. Cytoplasm. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
- Information by UniProt
This product has been referenced in:
- Hossain Z et al. Discovery of pancreastatin inhibitor PSTi8 for the treatment of insulin resistance and diabetes: studies in rodent models of diabetes mellitus. Sci Rep 8:8715 (2018). Read more (PubMed: 29880906) »
- Biswas N et al. Discovery of a novel target for the dysglycemic chromogranin A fragment pancreastatin: interaction with the chaperone GRP78 to influence metabolism. PLoS One 9:e84132 (2014). Functional Studies . Read more (PubMed: 24465394) »