Recombinant Human HBXIP protein (ab130038)

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Description

  • Product name

    Recombinant Human HBXIP protein

  • Purity

    > 90 % SDS-PAGE.
    ab130038 is purified using conventional chromatography techniques.

  • Expression system

    Escherichia coli

  • Accession

    O43504

  • Protein length

    Full length protein

  • Animal free

    No

  • Nature

    Recombinant

    • Species

      Human

    • Sequence

      MGSSHHHHHH SSGLVPRGSH MGSHMEPGAG HLDGHRAGSP SLRQALCDGS AVMFSSKERG RCTVINFVPL EAPLRSTPRS RQVTEACGGE GRAVPLGSEP EWSVGGMEAT LEQHLEDTMK NPSIVGVLCT DSQGLNLGCR GTLSDEHAGV ISVLAQQAAK LTSDPTDIPV VCLESDNGNI MIQKHDGITV AVHKMAS

    • Predicted molecular weight

      21 kDa including tags

    • Amino acids

      1 to 173

    • Tags

      His tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab130038 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Mass Spectrometry

  • Mass spectrometry

    MALDI-TOF

  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 0.32% Tris HCl, 0.03% EDTA, 10% Glycerol, 0.58% Sodium chloride

General Info

  • Alternative names

    • HBV X interacting protein
    • HBV X-interacting protein
    • HBX interacting protein
    • HBX-interacting protein
    • hbxip
    • HBXIP_HUMAN
    • Hepatitis B virus X interacting protein
    • Hepatitis B virus X-interacting protein
    • LAMTOR5
    • Late endosomal/lysosomal adaptor MAPK and MTOR activator 5
    • MGC71071
    • Ragulator complex protein LAMTOR5
    • XIP
    see all

  • Function

    When complexed to BIRC5, interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerized APAF1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway. Down-regulates hepatitis B virus (HBV) replication.

  • Tissue specificity

    Highly expressed in skeletal and cardiac muscle, followed by pancreas, kidney, liver, brain, placenta and lung. Elevated levels in both cancerous and non-cancerous liver tissue of patients with chronic HBV infection compared with hepatic tissue without HBV infection.

  • Sequence similarities

    Belongs to the HBXIP family.

  • Post-translational
    modifications

    Phosphorylated upon DNA damage, probably by ATM or ATR.

  • Cellular localization

    Cytoplasm.
  • Information by UniProt

Images

  • SDS-PAGE - Recombinant Human HBXIP protein (ab130038)
    SDS-PAGE - Recombinant Human HBXIP protein (ab130038)
    15% SDS-PAGE showing ab130038 (3 µg).

References

ab130038 has not yet been referenced specifically in any publications.

Publishing research using ab130038? Please let us know so that we can cite the reference in this datasheet.

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