Recombinant Human HBXIP protein (ab130038)

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SDS-PAGE - Recombinant Human HBXIP protein (ab130038)

    Key features and details

    • Expression system: Escherichia coli
    • Purity: > 90% SDS-PAGE
    • Tags: His tag N-Terminus
    • Suitable for: SDS-PAGE, MS

    Description

    • Product name

      Recombinant Human HBXIP protein

    • Purity

      > 90 % SDS-PAGE.
      ab130038 is purified using conventional chromatography techniques.

    • Expression system

      Escherichia coli

    • Accession

      O43504

    • Protein length

      Full length protein

    • Animal free

      No

    • Nature

      Recombinant

      • Species

        Human

      • Sequence

        MGSSHHHHHH SSGLVPRGSH MGSHMEPGAG HLDGHRAGSP SLRQALCDGS AVMFSSKERG RCTVINFVPL EAPLRSTPRS RQVTEACGGE GRAVPLGSEP EWSVGGMEAT LEQHLEDTMK NPSIVGVLCT DSQGLNLGCR GTLSDEHAGV ISVLAQQAAK LTSDPTDIPV VCLESDNGNI MIQKHDGITV AVHKMAS

      • Predicted molecular weight

        21 kDa including tags

      • Amino acids

        1 to 173

      • Tags

        His tag N-Terminus

    Specifications

    Our Abpromise guarantee covers the use of ab130038 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • Applications

      SDS-PAGE

      Mass Spectrometry

    • Mass spectrometry

      MALDI-TOF

    • Form

      Liquid
    • Concentration information loading...

    Preparation and Storage

    • Stability and Storage

      Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

      pH: 8.00
      Constituents: 0.32% Tris HCl, 0.03% EDTA, 10% Glycerol (glycerin, glycerine), 0.58% Sodium chloride

    General Info

    • Alternative names

      • HBV X interacting protein
      • HBV X-interacting protein
      • HBX interacting protein
      • HBX-interacting protein
      • hbxip
      • HBXIP_HUMAN
      • Hepatitis B virus X interacting protein
      • Hepatitis B virus X-interacting protein
      • LAMTOR5
      • Late endosomal/lysosomal adaptor MAPK and MTOR activator 5
      • MGC71071
      • Ragulator complex protein LAMTOR5
      • XIP
      see all

    • Function

      When complexed to BIRC5, interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerized APAF1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway. Down-regulates hepatitis B virus (HBV) replication.

    • Tissue specificity

      Highly expressed in skeletal and cardiac muscle, followed by pancreas, kidney, liver, brain, placenta and lung. Elevated levels in both cancerous and non-cancerous liver tissue of patients with chronic HBV infection compared with hepatic tissue without HBV infection.

    • Sequence similarities

      Belongs to the HBXIP family.

    • Post-translational
      modifications

      Phosphorylated upon DNA damage, probably by ATM or ATR.

    • Cellular localization

      Cytoplasm.
    • Information by UniProt

    Images

    • SDS-PAGE - Recombinant Human HBXIP protein (ab130038)
      SDS-PAGE - Recombinant Human HBXIP protein (ab130038)
      15% SDS-PAGE showing ab130038 (3 µg).

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    References (0)

    Publishing research using ab130038? Please let us know so that we can cite the reference in this datasheet.

    ab130038 has not yet been referenced specifically in any publications.

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