Overview

  • Product name

    Recombinant Human HCLS1 protein
  • Protein length

    Full length protein

Description

  • Nature

    Recombinant
  • Source

    Wheat germ
  • Amino Acid Sequence
    • Accession
    • Species

      Human
    • Sequence

      MWKSVVGHDVSVSVETQGDDWDTDPDFVNDISEKEQRWGAKTIEGSGRTE HINIHQLRNKVSEEHDVLRKKEMESGPKASHGYGGRFGVERDRMDKSAVG HEYVAEVEKHSSQTDAAKGFGGKYGVERDRADKSAVGFDYKGEVEKHTSQ KDYSRGFGGRYGVEKDKWDKAALGYDYKGETEKHESQRDYAKGFGGQYGI QKDRVDKSAVGFNEMEAPTTAYKKTTPIEAASSGARGLKAKFESMAEEKR KREEEEKAQQVARRQQERKAVTKRSPEAPQPVIAMEEPAVPAPLPKKISS EAWPPVGTPPSSESEPVRTSREHPVPLLPIRQTLPEDNEEPPALPPRTLE GLQVEEEPVYEAEPEPEPEPEPEPENDYEDVEEMDRHEQEDEPEGDYEEV LEPEDSSFSSALAGSSGCPAGAGAGAVALGISAVALYDYQGEGSDELSFD PDDVITDIEMVDEGWWRGRCHGHFGLFPANYVKLLE
    • Molecular weight

      80 kDa including tags
    • Amino acids

      1 to 486

Specifications

Our Abpromise guarantee covers the use of ab116926 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Western blot

    ELISA

  • Form

    Liquid
  • Additional notes

    Protein concentration is above or equal to 0.05 mg/ml. Best use within three months from the date of receipt of this protein.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names

    • Cortactin like
    • CTTNL
    • HCLS 1
    • Hcls1
    • HCLS1_HUMAN
    • Hematopoietic cell specific Lyn substrate 1
    • Hematopoietic cell-specific LYN substrate 1
    • Hematopoietic lineage cell-specific protein
    • HS 1
    • HS1
    • LckBP1
    • OTTHUMP00000215180
    • OTTHUMP00000215182
    • p75
    see all
  • Function

    Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression.
  • Tissue specificity

    Expressed only in tissues and cells of hematopoietic origin.
  • Sequence similarities

    Contains 4 cortactin repeats.
    Contains 1 SH3 domain.
  • Developmental stage

    Expressed in early stage of myeloid and erythroid differentiation.
  • Post-translational
    modifications

    Phosphorylated by LYN; rapidly after cross-linking of surface IgM on B-cells.
  • Cellular localization

    Membrane. Cytoplasm. Mitochondrion.
  • Information by UniProt

Images

  • 12.5% SDS-PAGE image showing ab116926 at approx 79.53 kDa. Stained with Coomassie Blue.

References

ab116926 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab116926.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
For licensing inquiries, please contact partnerships@abcam.com

Sign up