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Epigenetics and Nuclear Signaling Chromatin Modifying Enzymes Acetylation
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Recombinant Human HDAC2 protein (ab101662)

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SDS-PAGE - Recombinant Human HDAC2 protein (ab101662)
  • Functional Studies - Recombinant Human HDAC2 protein (ab101662)

Key features and details

  • Expression system: Baculovirus
  • Purity: > 70% SDS-PAGE
  • Suitable for: WB, Functional Studies

Description

  • Product name

    Recombinant Human HDAC2 protein
    See all HDAC2 proteins and peptides
  • Purity

    > 70 % SDS-PAGE.
    The purity of ab101662 was determined to be >70% by densitometry.
  • Expression system

    Baculovirus
  • Accession

    Q92769
  • Protein length

    Full length protein
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Human
    • Predicted molecular weight

      92 kDa including tags
    • Amino acids

      1 to 488

Associated products

  • Related Products

    • Anti-HDAC2 antibody [HDAC2-62] (ab12169)
    • Anti-HDAC2 antibody (ab16032)
    • Anti-HDAC2 antibody [Y461] (ab32117)
    • Anti-HDAC2 antibody [3F3] (ab51832)
    • Anti-HDAC2 antibody (ab7029)

Specifications

Our Abpromise guarantee covers the use of ab101662 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    Functional Studies

  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 7.50
    Constituents: 0.307% Glutathione, 0.00174% PMSF, 0.00385% DTT, 0.79% Tris HCl, 0.00292% EDTA, 25% Glycerol (glycerin, glycerine), 0.87% Sodium chloride

General Info

  • Alternative names

    • D10Wsu179e
    • HD 2
    • HD2
    • HDAC 2
    • Hdac2
    • HDAC2_HUMAN
    • Histone deacetylase 2
    • Histone deacetylase 2 (HD2)
    • OTTHUMP00000017046
    • OTTHUMP00000227077
    • OTTHUMP00000227078
    • RPD3
    • transcriptional regulator homolog RPD3
    • YAF1
    • YY1 associated factor 1
    • YY1 transcription factor binding protein
    • Yy1bp
    see all
  • Function

    Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.
    Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed of DNMT1, DMAP1, PCNA, CAF1. Deacetylates TSHZ3 and regulates its transcriptional repressor activity.
  • Tissue specificity

    Widely expressed; lower levels in brain and lung.
  • Sequence similarities

    Belongs to the histone deacetylase family. HD type 1 subfamily.
  • Post-translational
    modifications

    S-nitrosylated by GAPDH. In neurons, S-Nitrosylation at Cys-262 and Cys-274 does not affect the enzyme activity but abolishes chromatin-binding, leading to increases acetylation of histones and activate genes that are associated with neuronal development. In embryonic cortical neurons, S-Nitrosylation regulates dendritic growth and branching.
  • Cellular localization

    Nucleus.
  • Target information above from: UniProt accession Q92769 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

Images

  • SDS-PAGE - Recombinant Human HDAC2 protein (ab101662)
    SDS-PAGE - Recombinant Human HDAC2 protein (ab101662)
    The purity of ab101662 was determined to be >70% as determined by densitometry.
    Approximate molecular weight is ~92 kDa (with tag).
  • Functional Studies - Recombinant Human HDAC2 protein (ab101662)
    Functional Studies - Recombinant Human HDAC2 protein (ab101662)
    The specific activity of ab101662 was determined to be 4180 RLU/min/ng.

Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

Datasheets and documents

    • Datasheet
  • References (0)

    Publishing research using ab101662? Please let us know so that we can cite the reference in this datasheet.

    ab101662 has not yet been referenced specifically in any publications.

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