Description

  • Product name

    Recombinant human HDAC3 protein
    See all HDAC3 proteins and peptides
  • Biological activity

    Specific activity 125 RLU/min/ng.
  • Purity

    > 70 % SDS-PAGE.
    ab101663 is >70% pure as assessed by densitometry.
  • Expression system

    Baculovirus
  • Accession

  • Protein length

    Full length protein
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Human
    • Predicted molecular weight

      83 kDa including tags
    • Amino acids

      1 to 428

Specifications

Our Abpromise guarantee covers the use of ab101663 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Functional Studies

  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 7.50
    Constituents: 0.307% Glutathione, 0.00174% PMSF, 0.00385% DTT, 0.79% Tris HCl, 0.00292% EDTA, 25% Glycerol, 0.87% Sodium chloride

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names

    • HD3
    • HDAC 3
    • HDAC3
    • HDAC3_HUMAN
    • Histone deacetylase 3
    • RPD3
    • RPD3 2
    • RPD3-2
    • SMAP45
    see all
  • Function

    Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1; increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor. Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation.
  • Tissue specificity

    Widely expressed.
  • Sequence similarities

    Belongs to the histone deacetylase family. HD type 1 subfamily.
  • Post-translational
    modifications

    Sumoylated in vitro.
  • Cellular localization

    Nucleus.
  • Information by UniProt

Images

  • The specific activity of HDAC3 (ab101663) was determined to be 144 RLU/min/mg as per activity assay protocol
  • SDS PAGE analysis of ab101663
  • SDS PAGE analysis of ab101663
  • The specific activity of ab101663 was determined to be 125 RLU/min/ng.
  • The purity of HDAC3 was determined to be >70% as assessed by densitometry.
    The approximate molecular weight is ~83 kDa.

References

ab101663 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab101663.
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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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