Recombinant Human Hemoglobin subunit gamma 2 protein (ab139782)

Overview

  • Product name

    Recombinant Human Hemoglobin subunit gamma 2 protein
  • Protein length

    Full length protein

Description

  • Nature

    Recombinant
  • Source

    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species

      Human
    • Sequence

      MGSSHHHHHH SSGLVPRGSH MGSMGHFTEE DKATITSLWG KVNVEDAGGE TLGRLLVVYP WTQRFFDSFG NLSSASAIMG NPKVKAHGKK VLTSLGDAIK HLDDLKGTFA QLSELHCDKL HVDPENFKLL GNVLVTVLAI HFGKEFTPEV QASWQKMVTG VASALSSRYH
    • Molecular weight

      19 kDa including tags
    • Amino acids

      1 to 147
    • Tags

      His tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab139782 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Mass Spectrometry

  • Mass spectrometry

    MALDI-TOF
  • Purity

    > 90 % SDS-PAGE.
    ab139782 is purified using conventional chromatography techniques.
  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 0.02% DTT, 0.32% Tris HCl, 20% Glycerol, 0.58% Sodium chloride

General Info

  • Alternative names

    • Abnormal hemoglobin
    • FLJ76540
    • G gamma globin
    • Gamma 2 globin
    • Gamma-2-globin
    • Hb F Ggamma
    • HBG 2
    • HBG2
    • HBG2_HUMAN
    • Hemoglobin gamma 2 chain
    • Hemoglobin gamma G
    • Hemoglobin gamma G chain
    • Hemoglobin gamma-2 chain
    • Hemoglobin gamma-G chain
    • Hemoglobin subunit gamma 2
    • Hemoglobin subunit gamma-2
    • Methemoglobin
    • OTTHUMP00000069638
    see all
  • Function

    Gamma chains make up the fetal hemoglobin F, in combination with alpha chains.
  • Tissue specificity

    Red blood cells.
  • Involvement in disease

    Defects in HBG2 are the cause of cyanosis transient neonatal (TNCY) [MIM:613977]. TNCY is a disorder characterized by cyanosis in the fetus and neonate, due to a defect in the fetal hemoglobin chain which has reduced affinity for oxygen. Some patients develop anemia resulting from increased destruction of red cells containing abnormal or unstable hemoglobin. The cyanosis resolves spontaneously by 5 to 6 months of age or earlier, as the adult beta-globin chain is produced and replaces the fetal gamma-globin chain.
  • Sequence similarities

    Belongs to the globin family.
  • Developmental stage

    Expressed until four or five weeks after birth.
  • Post-translational
    modifications

    Acetylation of Gly-2 converts Hb F to the minor Hb F1.
  • Information by UniProt

Images

  • 15% SDS-PAGE analysis of ab139782 (3µg).

References

ab139782 has not yet been referenced specifically in any publications.

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