Overview

Description

  • Nature

    Recombinant
  • Source

    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species

      Human
    • Molecular weight

      29 kDa
    • Amino acids

      797 to 1046
    • Tags

      His-DHFR tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab127116 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Form

    Lyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20ºC.

    Constituents: 0.32% Tris HCl, 0.58% Sodium chloride

  • Reconstitution
    Reconstitute with water to desired concentration

General Info

  • Alternative names

    • DKFZP564G092
    • HECT and RLD domain containing E3 ubiquitin protein ligase 4
    • HECT domain and RCC1 like domain containing protein 4
    • HECT domain and RCC1-like domain-containing protein 4
    • Hect domain and RLD 4
    • HERC 4
    • HERC4
    • HERC4_HUMAN
    • KIAA1593
    • Probable E3 ubiquitin protein ligase HERC4
    • Probable E3 ubiquitin-protein ligase HERC4
    see all
  • Function

    Probable E3 ubiquitin-protein ligase involved in either protein trafficking or in the distribution of cellular structures. Required for spermatozoon maturation and fertility, and for the removal of the cytoplasmic droplet of the spermatozoon. E3 ubiquitin-protein ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer it to targeted substrates.
  • Tissue specificity

    Expressed in brain and testis and detected in heart and placenta.
  • Pathway

    Protein modification; protein ubiquitination.
  • Sequence similarities

    Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.
    Contains 7 RCC1 repeats.
  • Developmental stage

    Expressed in fetal brain.
  • Cellular localization

    Cytoplasm > cytosol. shows a punctate cytoplasmic distribution.
  • Information by UniProt

References

ab127116 has not yet been referenced specifically in any publications.

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