Description

  • Product name

    Recombinant Human HES2 protein
    See all HES2 proteins and peptides
  • Purity

    > 95 % Purified via His tag.
    Purity was determined to be >95% by SDS-PAGE.
  • Expression system

    Escherichia coli
  • Accession

  • Protein length

    Full length protein
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Human
    • Predicted molecular weight

      9 kDa
    • Amino acids

      1 to 76
    • Tags

      His-DHFR tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab127654 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Form

    Lyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20ºC.

    Constituents: 0.32% Tris HCl, 0.58% Sodium chloride

  • Reconstitution
    Reconstitute with 200µl water.

General Info

  • Alternative names

    • bHLHb40
    • Class B basic helix loop helix protein 40
    • Class B basic helix-loop-helix protein 40
    • Hairy and enhancer of split 2
    • Hairy and enhancer of split 2 (Drosophila)
    • Hes2
    • HES2_HUMAN
    • Transcription factor HES 2
    • Transcription factor HES-2
    see all
  • Function

    Transcriptional repressor of genes that require a bHLH protein for their transcription.
  • Tissue specificity

    Expressed in placenta, pancreatic cancer, colon cancer with RER, cervical cancer, and in head and neck tumors.
  • Sequence similarities

    Contains 1 bHLH (basic helix-loop-helix) domain.
    Contains 1 Orange domain.
  • Domain

    Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG).
    The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related proteins.
  • Cellular localization

    Nucleus.
  • Information by UniProt

References

ab127654 has not yet been referenced specifically in any publications.

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