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    recombinant-human-hexb-protein-ab198424.pdf

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Recombinant Human HEXB protein (ab198424)

  • Datasheet
  • SDS
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SDS-PAGE - Recombinant Human HEXB protein (ab198424)

    Key features and details

    • Expression system: Baculovirus infected Sf9 cells
    • Purity: > 82% SDS-PAGE
    • Tags: DDDDK tag C-Terminus
    • Suitable for: SDS-PAGE

    Description

    • Product name

      Recombinant Human HEXB protein
      See all HEXB proteins and peptides
    • Purity

      > 82 % SDS-PAGE.

    • Expression system

      Baculovirus infected Sf9 cells
    • Accession

      P07686
    • Protein length

      Full length protein
    • Animal free

      No
    • Nature

      Recombinant
      • Species

        Human
      • Sequence

        MELCGLGLPRPPMLLALLLATLLAAMLALLTQVALVVQVAEAARAPSVSA KPGPALWP LPLSVKMTPNLLHLAPENFYISHSPNSTAGPSCTLLEEAF RRYHGYIFGFYKWHHEPAE FQAKTQVQQLLVSITLQSECDAFPNISSD ESYTLLVKEPVAVLKANRVWGALRGLETFS QLVYQDSYGTFTINESTI IDSPRFSHRGILIDTSRHYLPVKIILKTLDAMAFNKFNVLHWHIV DDQ SFPYQSITFPELSNKGSYSLSHVYTPNDVRMVIEYARLRGIRVLPEFDTP GHTLSWG KGQKDLLTPCYSRQNKLDSFGPINPTLNTTYSFLTTFFKEI SEVFPDQFIHLGGDEVEFK CWESNPKIQDFMRQKGFGTDFKKLESFYI QKVLDIIATINKGSIVWQEVFDDKAKLAPGTI VEVWKDSAYPEELSRV TASGFPVILSAPWYLDLISYGQDWRKYYKVEPLDFGGTQKQK QLFIGG EACLWGEYVDATNLTPRLWPRASAVGERLWSSKDVRDMDDAYDRLTRHRC R MVERGIAAQPLYAGYCNHENMDYKDDDDKHHHHHH
      • Predicted molecular weight

        65 kDa including tags
      • Tags

        DDDDK tag C-Terminus

    Associated products

    • Related Products

      • Anti-DDDDK tag (Binds to FLAG® tag sequence) antibody (ab1162)
      • Anti-HEXB antibody [EPR7978] (ab140649)
      • Anti-DDDDK tag (Binds to FLAG® tag sequence) antibody (ab21536)

    Specifications

    Our Abpromise guarantee covers the use of ab198424 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • Applications

      SDS-PAGE

    • Form

      Liquid
    • Concentration information loading...

    Preparation and Storage

    • Stability and Storage

      Shipped on Dry Ice. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

      pH: 8.00
      Preservative: 1.02% Imidazole
      Constituents: 0.63% Tris HCl, 0.64% Sodium chloride, 0.02% Potassium chloride, 0.04% Tween, 20% Glycerol

    General Info

    • Alternative names

      • Beta hexosaminidase beta chain
      • Beta hexosaminidase subunit beta
      • Beta N acetylhexosaminidase
      • Beta-hexosaminidase subunit beta chain A
      • Beta-N-acetylhexosaminidase subunit beta
      • Cervical cancer proto oncogene 7 protein
      • Cervical cancer proto-oncogene 7 protein
      • ENC 1AS
      • Epididymis luminal protein 248
      • HCC 7
      • HCC-7
      • HCC7
      • HEL 248
      • HEX B
      • Hexb
      • HEXB_HUMAN
      • Hexosaminidase B
      • Hexosaminidase B (beta polypeptide)
      • Hexosaminidase subunit B
      • HexosaminidaseB
      • N acetyl beta glucosaminidase
      • N-acetyl-beta-glucosaminidase subunit beta
      see all
    • Function

      Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues.
    • Involvement in disease

      Defects in HEXB are the cause of GM2-gangliosidosis type 2 (GM2G2) [MIM:268800]; also known as Sandhoff disease. GM2-gangliosidosis is an autosomal recessive lysosomal storage disease marked by the accumulation of GM2 gangliosides in the neuronal cells. GM2G2 is clinically indistinguishable from GM2-gangliosidosis type 1, presenting startle reactions, early blindness, progressive motor and mental deterioration, macrocephaly and cherry-red spots on the macula.
    • Sequence similarities

      Belongs to the glycosyl hydrolase 20 family.
    • Post-translational
      modifications

      N-linked glycans at Asn-142 and Asn-190 consist of Man(3)-GlcNAc(2) and Man(5 to 7)-GlcNAc(2), respectively.
      The beta-A and beta-B chains are produced by proteolytic processing of the precursor beta chain.
    • Cellular localization

      Lysosome.
    • Target information above from: UniProt accession P07686 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt

    Images

    • SDS-PAGE - Recombinant Human HEXB protein (ab198424)
      SDS-PAGE - Recombinant Human HEXB protein (ab198424)

      4-20% SDS-PAGE Coomassie staining.

      Lane 1: 2.8 µg ab198424

      Lane 2: Protein Marker

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    Datasheets and documents

    • Datasheet
    • SDS
  • References (0)

    Publishing research using ab198424? Please let us know so that we can cite the reference in this datasheet.

    ab198424 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

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